Director/Senior Director, Supply Chain

About the role

Xenon Pharmaceuticals ( NASDAQ:XENE ) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. What We Do: We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. We are seeking a Director/Senior Director, Supply Chain to lead and manage the key strategic activities from clinical development through commercial readiness and launch. This role is accountable for building scalable, compliant, and resilient supply chain capabilities while operating effectively in an environment of ambiguity, rapid change, and aggressive timelines. The ideal candidate will be a strategic partner working with cross-functional leaders to support this critical next step for Xenon. The ideal candidate can balance speed with accuracy, apply critical thinking with the information available, and ensure integrated planning, capacity management, systems, and governance as programs advance toward commercialization. This leader will be both strategic and hands‑on, capable of setting direction while driving execution across multiple programs and external partners. This position reports to the Executive Director, Supply Chain and will be based out of Boston, MA, USA in our Needham office. We may consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate's education and industry experience. Hybrid positions require a minimum of two onsite days per week.

Responsibilities

• Establish and mature S&OP or equivalent integrated planning forums, enabling clear visibility to trade‑offs, constraints, and executive decision points. Lead scenario planning to evaluate alternative demand and supply assumptions and inform capacity decisions and risk‑mitigation strategies.
• Lead supply chain readiness for key commercialization milestones, including activities such as: late‑stage clinical supply continuity and transition planning, commercial supply chain design and distribution model definition commercial lot readiness and launch inventory build
• Ensure supply chain deliverables are aligned with regulatory submissions, labeling, serialization, and market launch requirements.
• Support launch execution and early commercial stabilization, including issue resolution, perf

Benefits

Your Match

How well this role fits your profile.

Company Intel

What employees say

Worked at Xenon Pharmaceuticals? Share your experience