Senior Site Contracts Manager (Sponsor Dedicated /Remote - US Based)

About the role

As a Senior Site Contracts Manager , you'll serve as a strategic expert responsible for developing, negotiating, and managing US site budgets and clinical trial agreements. You'll collaborate closely with internal teams, external stakeholders, and major academic institutions to craft robust contracts that support operational excellence while minimizing risk. This role is perfect for a communicator, leader, and negotiator who's ready to hit the ground running and make an immediate impact.

Responsibilities

• Budgeting & Template Development
• Negotiate budgets from start to finish from a Sponsor perspective directly with clinical sites.
• Fully understand budget and contract language for Pharma & Vaccine clinical trials.
• Develop and refine templates to support consistency, compliance, and strategic study needs.
• Contract Negotiation & Risk Management
• Lead direct negotiations with large academic institutions and other critical stakeholders.
• Draft and finalize clinical trial agreements that balance business objectives with legal and operational protections.
• Conduct due diligence checks-such as FMV assessments and site justification reviews-when initial offers are declined.
• Determine when requests require budget or language escalation and secure appropriate approvals.
• Project Leadership & Delivery
• Prioritize and lead multiple contracting projects across several therapeutic areas (oncology experience strongly preferred).
• Proactively escalate risks, timeline impacts, or delays that could affect CTA execution.
• Tools, Systems & Communication
• Demonstrate expert proficiency in Excel and clinical trial management systems.
• Communicate effectively in both written and verbal formats, incorporating feedback seamlessly.
• Maintain accurate and timely updates in departmental trackers and databases.
• Compliance, Collaboration & Continuous Improvement
• Deepen and maintain knowledge of GCP, sponsor processes, SOPs, work instructions, and new technologies.
• Build strong working relationships with internal and external partners.
• Support and train additional team members as needed.
• Contribute to process improvement initiatives that simplify workflows and eliminate inefficiencies.
• Take on ad‑hoc tasks and diverse projects with a solutions‑oriented mindset.

Requirements

• Oncology therapeutic area experience
• Prior experience with pharma, CRO, or investigative sites
• Strong project management skills and comfort leading cross‑functional efforts
• Experience leveraging AI in the contracts and budgets space
• What You Bring (Minimum qualifications):
• 4+ years of experience working in a fast paced and volume driven work environme

Benefits

Additional Information

Senior Site Contracts Manager (Sponsor Dedicated /Remote - US Based) Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress. Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape. Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you'll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver - for one another, our customers, and, most importantly, for those in need. Discover what your 25,000 future colleagues already know: Why Syneos Health - We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program. - We are committed to building an inclusive culture - where you can authentically be yourself. Central to this is our purpose - Driven to Deliver - which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone's life. - We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress. Job Responsibilities Senior Site Contracts Manager (Sponsor‑Dedicated /Remote - US Based) Are you a contracts expert who thrives on navigating complexity, building strong site partnerships, and driving timelines forward? Syneos Health is seeking a Senior Site Contracts Manager to support a sponsor‑dedicated program focused on high‑impact Pharma & Vaccine studies. If you're energized by problem‑solving, negotiation, and leading projects across multiple therapeutic areas-especially oncology-we'd love to meet you.

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