Associate Scientist, Synthesis Process Development

Requirements

• BS with 1 + years of industry experience, or MS with relevant experience, in Chemical Engineering, Biomedical Engineering, Biochemistry, or a related scientific discipline
• Hands-on experience with RNA synthesis techniques, specifically in vitro transcription
• Familiarity with analytical tools used to assess RNA quality, including gel electrophoresis, HPLC, or capillary electrophoresis
• Basic understanding of RNA purification unit operations
• Strong laboratory fundamentals and attention to detail; comfortable working with bench-top equipment including bioreactors, FPLCs, and UF/DF skids
• Ability to organize and analyze experimental data, identify trends, and clearly communicate results to team members
• Exposure to GMP principles or cGMP environments is a plus but not required
• Experience with design of experiments (DoE) or statist

Additional Information

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . Bristol Myers Squibb is on a mission to discover, develop, and deliver innovative medicines that help patients prevail over serious diseases. Guided by a commitment to rigorous science, integrity, and transformative innovation, BMS is a global biopharma leader dedicated to improving the lives of patients worldwide. In October 2025, BMS significantly expanded its RNA medicines capabilities through the acquisition of Orbital Therapeutics, bringing with it a powerful and differentiated RNA platform that combines circular and linear RNA engineering, advanced delivery technologies, and AI-driven design. This platform is accelerating BMS's efforts to pioneer a new generation of programmable RNA therapies across immunomodulation for autoimmune disease and oncology, next-generation vaccines, and protein therapeutics. As we continue to grow and integrate this exciting RNA platform, we are building out a world-class RNA Process Development team based in Cambridge, MA. If you are passionate about cutting-edge RNA science and want to contribute to medicines that have the potential to transform patient lives in ways not previously possible, we invite you to join us. Position Summary Bristol Myers Squibb is seeking a motivated and detail-oriented Associate Scientist to join our RNA Synthesis Process Development team in Cambridge, MA. The RNA PD team works to develop, characterize, and implement robust preclinical and clinical manufacturing processes to support Bristol Myers Squibb's exciting pipeline of products. This role is specifically focused on RNA synthesis process development, with responsibilities spanning early process development through clinical manufacturing support. This is an excellent opportunity for an early-career scientist to grow within a dynamic, fast-paced environment. The successful candidate will support planning and execution of laboratory studies and contribute to protocols, technical reports, and regulatory documentation under the guidance of senior team members. Job Responsibilities Execute hands-on laboratory experiments focused on RNA synthesis process development and scale-up from bench to pilot scale Design and perform experiments for optimization and characterization of in vitro transcription reactions using structured approaches (i.e. QbD principles, DoE) Support routine downstream purification unit operations (e.g. chromatography, UF/DF) and contribute to process optimization efforts that bridge synthesis and purification workflows Contribute to the authoring and review of technical protocols, experimental reports, and batch records in support of early- to late-stage development activities Perform routine analytical testing to assess RNA purity, concentration and key quality attributes Analyze and interpret experimental results, present findings to senior scientists and project teams Collaborate with internal R&D, analytical development, and manufacturing to advance BMS's RNA pipeline Support interactions with manufacturing partners, including review of technical documents and participation in technology transfer activities as needed Maintain accurate and complete laboratory notebooks and documentation in compliance with internal quality standards

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