Senior Scientist, Computational Protein Design

Responsibilities

• Design and execute Synteins TM engineering campaigns to generate drug candidates.
• Create computational design strategies to deliver drug candidates drawing from array of ML tools and Rosetta scripts.
• Collaborate with computation, chemistry, and experimental biology teams to optimize designs for function, solubility, and stability.
• Integrate structural and biophysical data (e.g., binding, CD, HDX-MS, CryoEM) into iterative optimization cycles

Requirements

• Required
• PhD in structural biology, biophysics, protein design, or related field
• 2+ years of hands-on experience in structure-guided protein design
• Demonstrated proficiency with modern structure prediction and design tools such as RFdiffusion, proteinMPNN, AF2, Boltz2, BoltzGen, Rosetta or equivalent SOTA tools for in-silico protein engineering.
• Strong understanding of the biophysics of protein folding and interface energetics
• Demonstrated ability to progress designs from concept to experimental testing
• Excellent communication skills
• Preferred
• Experience designing minibinders or proteins
• Familiarity with non-canonical amino acid design
• Familiarity with molecular dynamics tools.
• Exposure to high-throughput or automated protein engineering environments
• Prior work on platform-based or early-stage biotech teams
• Why Join Abiologics
• Help invent a new class of programmable synthetic proteins
• Be part of a high-velocity discovery platform with real-time synthesis and screening
• Collaborate with a deeply interdisciplinary, mission-driven team
• Redefine the limits of what proteins can do
• ABOUT FLAGSHIP PIONEERING:
• At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
• We are an equal opportunity employer . All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

Benefits

Additional Information

About Abiologics Abiologics is a Flagship Pioneering company developing Synteins™ - a transformative class of fully synthetic proteins composed entirely of artificial building blocks such as D-amino acids and non-canonical residues. Synteins TM are designed to transcend the limitations of traditional biologics, with improved oral stability, immune evasion, and metabolic durability - all while being fully programmable by design. Powered by a proprietary AI-enabled discovery platform, Abiologics integrates generative design , automated synthesis , and rapid experimental screening to enable iterative optimization at scale. Position Summary We are seeking a Protein Design Scientist to join the Computational Protein Design team and help drive structure-based design and optimization of synthetic proteins. This is a highly interdisciplinary role at the interface of computational design, structural biology, and protein engineering. Ideal candidates have deep experience in de novo protein design , miniproteins , and binders engineering and are eager to push the boundaries of non-natural protein design in a fast-moving, data-rich environment.

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