Staff Scientist-LCMS

Responsibilities

• Develop and optimize targeted LC-MS methods (MRM/PRM) for small molecules, lipids, and/or peptides
• Design and refine LC gradients to achieve optimal separation, sensitivity, and throughput
• Optimize MS/MS parameters (collision energy, resolution, scan speed, dwell time)
• Establish and implement quantification strategies (internal standards, calibration curves, QC normalization)
• Evaluate assay performance: precision, accuracy, linearity, dynamic range, LLOQ/ULOQ
• Assess and mitigate matrix effects and ion suppression
• Operate and troubleshoot high-resolution MS systems (e.g., Orbitrap) and/or triple quadrupole platforms
• Support method transfe r across instruments and sites
• Integrate workflows with automated sample preparation systems
• Document methods and support CLIA/FDA-aligned validation and SOP development

Requirements

• PhD (or MSc with strong experience) in Analytical Chemistry, Biochemistry, or related field
• 5+ years of experience in targeted LC-MS method development
• Hands-on expertise with PRM (HRMS)
• Strong understanding of quantitative LC-MS workflows in biological matrices
• Preferred:
• Experience in lipidomics, proteomics, or clinical assays
• Familiarity with regulated environments (CLIA/FDA/ISO)
• Experience with high-throughput or automated workflows
• Experience with biological specimens.
• Experience with high resolution mass spectrometry
• AI & Digital Fluency
• Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.
• Primary Location: Palo Alto, CA
• Primary Location Base Pay Range: $150,100 - $206,400
• Other US Location(s) Base Pay Range: $127,585 - $175,440
• If the role is performed in Colorado, the pay range for this job is: $135,090 - $185,760
• Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com
• All your information will be kept confidential accord

Benefits

Additional Information

Company Description Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn , X (Twitter) and Facebook .

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