Postdoctoral Fellow - Immune Cell Dynamics - Optogenetics

About the role

The Parsa Lab, also known as the Immune Cell Dynamics and Function group, is currently accepting applications for a Postdoctoral fellow position. The Parsa group focuses on investigating the cellular and functional dynamics of T cells, exploring how T cell fate decisions are made and how these decisions impact their functions in different disease contexts. Using a combination of genetically engineered mice, disease models, and single-cell technologies, we aim to uncover the principles governing T cell fate and their functional roles across tissues. This position is to develop novel methods and tools to determine the migratory dynamics of immune cells, with focus on T cells, and how that affects their cellular profile, function and longevity. It is an outstanding opportunity to collaborate with a team of talented scientists working to address fundamental immunological questions, with potential applications in treating inflammatory disorders, autoimmunity, and cancer. More information can be found at https://parsalab.org Interested candidates should submit the following documents: Cover Letter detailing research interests, motivations and career goals. Full version of Curriculum Vitae (CV) highlighting major achievements, summary of a significant publication, and includes contact information for 3 references (letters will be requested as needed)

Responsibilities

• Conduct independent and collaborative research in immunology and related areas
• Design and perform in vitro and in vivo immune cell assessment
• Establish tools and perform assays to assess immune cell migration
• Design, execute and analyze experiments
• Present experimental data (in both written and oral formats)
• Prepare manuscripts for publication in peer-reviewed journals
• Follow advances in the field through published literature and conferences
• Work closely with fellow team members and other members at Biohub institutions
• Mentor research assistants and interns in the lab

Requirements

• Essential:
• PhD degree in immunology, molecular biology, genetics, biochemistry, or a related field
• Proficiency in molecular cloning, CRISPR gene editing, and generation of constructs for viral transduction methods
• A strong sense of curiosity and drive to explore
• Demonstrated ability to conduct independent research and work in a team
• Excellent communication skills (both verbal and written)
• Ability to collaborate in a diverse environment
• Strong applicants have skills in one or more of the following areas:
• Experience working with mice, particularly generating transgenic or genetically modified primary T cells (and mice).
• Experience with flow cytometry and microscopy (particularly bioluminescence and fluorescence microscopy), and other imaging modalities to detect and quantify reporter gene expression
• Strong knowledge of the existing literature in immunology, dogmas and challenges

Benefits

Additional Information

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere. The Team Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer's, and Parkinson's. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here . Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Our Vision Pursue large scientific challenges that cannot be pursued in conventional environments Enable individual investigators to pursue their riskiest and most innovative ideas Facilitate research by scientists and clinicians at our home institutions and beyond We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.

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