Sr. Scientist, Biomarker Discovery

Responsibilities

• Lead and execute clinical and translational biomarker research to establish mechanism of action, target engagement, and immune pathway modulation for clinical-stage immunology therapeutics.
• Independently design, perform, analyze, and interpret experiments using primary human samples to generate robust, decision-enabling biomarker data.
• Develop, optimize , and own multiparameter flow cytometry-based clinical biomarker assays, including immune phenotyping, receptor occupancy, and pharmacodynamic readouts.
• Support assay qualification, method transfer to CROs, and longitudinal clinical biomarker data review, ensuring assay robustness and interpretability.
• Communicate biomarker insights clearly to cross-functional stakeholders to influence clinical strategy, study interpretation, development decision, and scientific narrative.

Requirements

• Required Skills:
• PhD in Immunology or related biomedical science field (Bachelors or Masters with additional directly relevant experience may be considered).
• 2 + years of relevant industry or translational research experience supporting clinical-stage immunology programs (6+ years with MS , 8+ years with BS ).
• Expertise in flow cytometry based assays and biomarker development.
• Strong analytical and experimental skills in immunology research.
• Excellent communication skills to convey scientific insights effectively.
• Preferred Skills:
• Experience in assay qualification and method transfer to CROs.
• Proficiency in immune phenotyping, receptor occupancy, and pharmacodynamic readouts.
• Familiarity with clinical biomarker data review and interpretation.
• Job Level: Management
• Additional Information
• The base compensation range for this role is: $123,000.00-$164,000.00
• Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
• Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
• In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being ; including, but not limited to:
• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation
• Why Biogen?

Benefits

Additional Information

About This Role: As a Sr. Scientist in Biomarker Discovery, you will play a pivotal role in advancing immunology therapeutics within our organization. Working with the WCH team, you will lead and execute cutting-edge biomarker research across non-clinical and clinical stages. Your expertise will be crucial in generating high-quality biomarker data from non-human primate and human samples, focusing on mechanism of action, target engagement, and immune pathway modulation. This position requires a strong hands-on approach to experimental work, particularly in flow cytometry-based assays, while collaborating closely with clinical and translational partners. Your contributions will be essential in bridging immune biology with clinical development, providing decision-enabling insights that drive clinical strategies and therapeutic advancements.

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