Scientist I - Complex In Vitro Models

Responsibilities

• Routine culture and maintenance of immortalized and primary cell cultures, both in standard formats as well as organoids or organ-on-chip formats.
• Isolation of primary human cells from various sources including tissue and whole blood.
• Work with a Senior Scientist to develop complex in vitro models that mimic the pathophysiology of immune mediated diseases with a focus on IBD
• Design, perform, and interpret in vitro experiments to support drug discovery and development activities. This may include mechanism of action experiments to advance target identification and validation efforts in immunology and IBD.
• Conduct experiments with a high level of independence and initiative and performing tasks with minimal direct supervision for routine methods.
• Independently schedule and prioritize workload to manage several tasks simultaneously
• Maintain detailed electronic documentation to ensure adherence to departmental procedures and contribute to final reports as needed.
• Interact with other scientists within a matrixed environment including to identify / utilize resources outside of your own group and presenting findings to audiences with diverse backgrounds (e.g., immunologists, cell biologists, pathologists, bioengineers).
• Bachelor's Degree with typically 5 years of experience, or Master's Degree with typically two years of experience.
• Experience working with human tissue samples and with isolating and characterizing cells such as epithelial, fibroblast, endothelial, and/or immunological (B cells, T cells, monocytes). Extensive experience with primary cell cultures and in vitro cell based assays.
• Demonstrated proficiency in cell and molecular biological assays such as qPCR analysis, multicolor flow cytometry, FACS, ELISA/Luminex/MSD, cell proliferation/viability assays, cytotoxicity assays
• Experience in 3D tissue modeling (i.e. spheroids, organoids, commercially available organ-on-a-chip platforms, microfluidics) is a plus.
• Strong written and oral communication skills are important.
• Ability to build relationships and work collaboratively with cross-functional teams in a highly matrixed organization.
• Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
• US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
• US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
• https://www.abbvie.com/join-us/reasonable-accommodations.html

Benefits

Additional Information

We are seeking a highly motivated Scientist to join the Gastroenterology Immunology Discovery team. Together with a Senior Scientist, this position will drive the development and deployment of complex in vitro models to support AbbVie's drug discovery efforts. This is a hands-on and lab-based role requiring significant cell biology expertise. The ideal candidate will have extensive experience with primary cell cultures and in vitro cell-based assays in the context of autoimmune disease.

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