Senior Vice President, Program Leadership & Development

About the role

This is a unique opportunity to shape and define how program leadership is executed within a growing biotech organization at a critical inflection point. Build a New Function from the Ground Up - design and implement a modern program leadership model, including the evolution from traditional program management to a strategic Program Lead and Program Manager structure. Operate as a True Peer to Clinical and Medical Leadership - serve as an equal partner to senior leaders across Clinical Operations, Medical, and Regulatory, helping shape asset strategy and execution. Drive Impact Across the Full Development Lifecycle - lead programs spanning early-phase IND-enabling work through Phase 3 and potential NDA submission, with direct impact on key value-driving milestones. Balance Strategy and Execution in a Lean Environment - play a dual role as both a strategic leader and hands-on program leader, directly influencing outcomes while building for future scale. Shape Organizational Culture and Ways of Working - establish a highly collaborative, accountable, and transparent operating model that strengthens alignment across functions and reduces organizational friction. Scale with the Portfolio - build and develop a high-performing team over time, aligned to the growth of the pipeline and key clinical milestones.

Responsibilities

• Strategic Program Leadership
• Partner with Clinical Operations and Medical leadership to define and execute development strategies and plans across programs
• Drive program-level decision-making, including risk assessment, trade-offs, and prioritization
• Ensure alignment between asset strategy, clinical execution, and regulatory pathways
• Present program updates, risks, and opportunities to Executive Leadership and Board of Directors
• Cross-Functional Integration & Alignment
• Serve as the central integrator across Medical, Clinical Operations, Regulatory, Biometrics, CMC, Commercial and other key functions
• Drive clarity of roles, decision-making, and accountability across program teams
• Proactively identify and resolve cross-functional misalignment, gaps, and competing priorities
• Hands-On Program Execution
• Directly serve as Program Lead for one or more key assets, particularly in the early phase of the role
• Lead cross-functional team meetings, execution planning, and milestone delivery
• Translate strategic objectives into clear, aligned execution plans
• Build & Scale Program Leadership
• Design and implement a program leadership model, including Program Leads and Program Managers
• Hire, develop, and lead program leadership talent over time as the organization grows
• Establish best practices, governance frameworks, and ways of working that enable scalability
• Portfolio & Executive Contribution
• Contribute to portfolio prioritization, resource allocation, and strategic planning discussions at the leadership level
• Provide clear, actionable insights and recommendations to executive leadership
• Support the evolution of Amylyx's development organization as it scales toward key clinical and regulatory milest

Additional Information

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values - be audacious, be curious, be authentic, be engaged, and be accountable - creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine's toughest problems, we encourage you to read the opportunity below and apply. The Position Reporting to our Co-CEO's, the SVP of Program Leadership & Development will drive the advancement of our clinical-stage pipeline. This individual will be responsible for end-to-end leadership of one or more key development programs translating scientific innovation into clinical, regulatory, and commercial success. The SVP of Program Leadership & Development will play a critical role in shaping program strategy, guiding cross-functional execution, and maximizing asset value from early development through late-stage trials and potential regulatory approval. This role will serve as a core member of the Senior Leadership Team, partnering closely with Clinical Operations, Medical, Regulatory, Biometrics, CMC, Commercial and other functional leaders to drive the successful execution of Amylyx's development portfolio. In a lean and evolving biotech environment, this individual will operate both as an enterprise leader and a hands-on program leader, directly supporting key assets while building a scalable program leadership organization over time.

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