Senior Statistician II, Late Oncology

About the role

Senior Statistician II, Late Oncology Introduction to role Are you ready to turn complex data into decisions that shape late-stage oncology development? Do you want your statistical judgment to be visible at the moments that matter for patients and the business? In this high-exposure role, you will guide the building, analysis and understanding of studies that inform pivotal decisions across our late oncology portfolio. You will partner with clinicians, clinical operations, regulatory and medical teams to bring statistical rigor to every stage of development-translating evidence into clear recommendations that accelerate delivery of life-changing medicines. You will operate at the intersection of science and decision-making: applying robust methods, stress-testing strategies through modelling and simulation, and communicating insights with clarity. You will be supported by experienced peers, yet trusted to own your work, improve how we operate, and help set the bar for quality across programs. Accountabilities: Offer statistical support for planning experimental work and clinical studies. Build clear decision criteria and power plans to address the right questions with relevant evidence. With mentorship from experienced statisticians, lead the development and analysis of complex studies. Support broader programs including preclinical investigations, regulatory submissions, commercialization activities, and interactions with senior governance bodies. Simulation and modelling: Apply simulation and modelling to inform study build decisions, assess robustness and operating characteristics, and examine scenarios under pressure to minimize risks in development plans. Analysis Planning and Execution: Develop Statistical Analysis Plans; produce analyses, graphics and tables for standard studies and reports across clinical, preclinical, medical affairs and publication needs with accuracy and timeliness. Insightful Interpretation and Communication: Interpret, summarize and communicate findings from standard studies in a way that influences decisions and next steps, translating statistics into clear, actionable mentorship. Methodology and Process Improvement: contribute to improving methods and practical solutions that increase quality, efficiency, and effectiveness. Embed guidelines in planning, conducting, and reporting studies. Manage your work to meet deadlines and standards. Be accountable for your statistical deliverables' integrity. Provide discipline-specific insight and constructive challenge. Recognize your own development needs. Essential Skills/Experience: MS required; PhD preferred in statistics or related field Provides statistical expertise for study design, analysis, and interpretation in both research projects and clinical trials Independently leads statistical elements of project work, develops Statistical Analysis Plans, and generates analyses, graphics, and tables for preclinical and clinical studies Applies modelling, simulation, and a range of advanced statistical methods to inform and improve study design and the robustness of results Collaborates with senior statisticians and contributes to broader programs including preclinical research, regulatory submissions, commercialization efforts, and internal governance Offers practical solutions and improvements to statistical methodologies, processes, and project guidelines Clearly interprets, summarizes, and communicates study results to multidisciplinary teams and collaborators Maintains high standards of quality and accountability in statistical work, provides thoughtful critique, and is proactive about personal development Effectively solves complex problems within own area and works collaboratively within multidisciplinary teams Desirable Skills/Experience: Experience in late-stage oncology trials along with knowledge of disease endpoints and estimands Proficiency in SAS and R, with experience in reproducible workflows and version control Familiarity with regulatory guidelines and submissions, including ICH E9 and related addenda Experience with Bayesian or simulation-based design approaches and decision frameworks Strong communication skills to influence non-statistical partners and present at governance forums Record of contributions to publications or conference presentations Great People want to Work with us! Find out why: GTAA Top Employer Award for 11 years Top 100 Employers Award Canada's Most Admired Corporate Culture Learn more about working with us in Canada View our YouTube channel Are you interested in working at AZ, apply today! AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca

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