Research Specialist A

Responsibilities

• Assist senior lab members with ongoing projects
• Perform molecular biology techniques including DNA/RNA preparation, PCR, RT-qPCR, cloning, plasmid construction, and CRISPR-based functional screens
• Execute cell biology and imaging assays including immunofluorescence and confocal microscopy
• Contribute to epigenomic and genomic studies including next-generation sequencing sample preparation and related workflows
• Support stem cell and developmental biology projects including culture and differentiation of iPSCs
• Assist with mouse colony maintenance including breeding setup, genotyping, record keeping, and coordination with animal facility staff
• Maintain accurate, organized, and reproducible records of experimental procedures, results, sample inventories, and data analyses
• Participate in laboratory maintenance including ordering supplies, inventory management, reagent preparation, equipment maintenance.
• Required Qualifications
• Bachelor's degree in biology, molecular biology, cell biology, genetics, biochemistry, cancer biology, or a related field and 0-1 year of experience or equivalent combination of education and experience required.
• Prior research experience in an academic or biomedical laboratory with a demonstrated ability to conduct careful, rigorous, and reproducible science
• Hands-on experience in molecular biology, cloning, mammalian cell culture, and animal work.
• Ability to learn new technologies, manage multiple tasks, communicate effectively, and work with attention to detail and scientific integrity

Requirements

• Experience with confocal microscopy, quantitative imaging, and image analysis
• Experience with molecular cloning, viral production, pooled genetic screens, next-generation sequencing sample preparation, and epigenomic/transcriptomic assays
• Experience with iPSC and organoid culture, differentiation systems, developmental biology models, or cancer model systems
• Interest in chromatin biology, biomolecular condensates, cancer epigenetics
• Professional Growth Oppor

Benefits

Additional Information

University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023. Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play. The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more. Posted Job Title Research Specialist A Job Profile Title Research Specialist A Job Description Summary The Wan Lab at the University of Pennsylvania Perelman School of Medicine is seeking a highly motivated Research Specialist to join our team studying basic mechanisms of gene regulation and how their dysregulation contributes to cancer and developmental disease. Specifically, we employ multidisciplinary approaches to understand how chromatin-associated factors and their aberrant assemblies influence chromatin function and gene regulation at the molecular level, and how these mechanisms control cell fate during development and tumorigenesis. We are also actively leveraging these insights to develop novel therapeutic strategies. This position offers an exceptional training opportunity to contribute to impactful research in a cutting-edge laboratory environment. The candidate will work closely with the Principal Investigator, senior postdoctoral fellows, graduate students, and other lab members to support multiple ongoing projects, particularly those focused on biomolecular condensates, chromatin and transcriptional regulation, and developmental epigenetics. Our lab is affiliated with the Department of Cancer Biology, the Abramson Family Cancer Research Institute, the Penn Epigenetics Institute, and the Institute for Regenerative Medicine, providing the candidate with a rich academic environment and a dynamic community for professional development beyond the lab. Position in contingent on continued grant support. Job Description

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