Principal Scientist, Upstream Process Science

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Company Overview ImmunityBio, Inc. (NASDAQ: IBRX) is a commercial-stage biotechnology company developing cell and immunotherapy products that are designed to help strengthen each patient's natural immune system, potentially enabling it to outsmart the disease and eliminate cancerous or infected cells. We envision a day when we no longer fear cancer, but can conquer it, thanks to the biological wonder that is the human immune system. Our scientists are working to develop novel therapies that harness that inherent power by amplifying both branches of the immune system, attacking cancerous or infected cells today while building immunological memory for tomorrow. The goal: to reprogram the patient's immune system and treat the host rather than just the disease. Why ImmunityBio? - ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases. - Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California. - Work with a collaborative team with the ability to work across different areas of the company. - Ability to join a growing company with professional development opportunities. Position Summary The Principal Scientist, Upstream Process Sciences role will manage the team responsible for upstream process development, process characterization, and scientific support activities for GMP manufacturing. This role serves as a technical expert for specific unit operations within the upstream manufacturing process, including both microbial and cell culture seed expansions and bioreactor operations across multiple cell lines. This role is also responsible for designing and executing process development experiments to design a robust and scalable clinical and commercial production process. Essential Functions Lead and advise internal and external teams in development of efficient and robust microbial and cell culture production for whole cell products, viral vector, recombinant monoclonal antibodies, Fc-fusion, and other proteins for research, clinical, and commercial manufacturing. Provide high-level technical knowledge in the development of batch, fed batch, and perfusion processes for inoculum expansion and biologics production operations. Manage the day-to-day activities of the team to include the hiring and training of new team members, coaching employees and monitoring performance Provide project coordination and high-level technical expertise in process development, process improvement, scale-up, and tech transfer activities. Guide and advise other technical staff in risk assessment, Design of Experiments (DOE), process characterization, process validation, and process monitoring activities. Provide input for development programs, and collaborate with discovery, formulation, analytical, quality, regulatory and manufacturing teams. Draft, review and approve technical protocols, reports, and manufacturing deviation investigations. Present activities and results interdepartmentally, and to senior management. Perform ad-hoc and cross-functional duties and/or projects, as assigned, to support business needs and provide developmental opportunities. Author and review process-related regulatory submissions. Conducts daily tasks associated with development and characterization of novel human therapeutics. Responsible for laboratory equipment maintenance programs. Create, edit and adhere to Standard Operating Procedures (SOPs). Performs ad-hoc and cross-functional duties and/or projects assigned to support business needs and provide developmental opportunities. Education & Experience Ph.D. in Cell Biology, Microbiology, Biology, or other life science or related field with 6+ years of experience in biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required; or MSc in Cell Biology, Microbiology, Biology, or other life science or related field with 9+ years of experience biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required; or Bachelor's degree in Cell Biology, Microbiology, Biology, or other life science or related field with 12+ years of biopharmaceutical-based process development and/or GMP manufacturing operations including direct experience in upstream processes required. Extensive experience in method development, method validation, and method transfer is required. Previous supervisory experience strongly preferred Knowledge, Skills, & Abilities Fundamental knowledge of cell and molecular biology, immunology, and/or virology Possess a high level of honesty and integrity, highly motivated and detail oriented. Expertise in developing upstream biopharmaceutical production processes. In-depth knowledge of statistical desig

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