Scientist - Off-Target Genomics (Gene Therapy)
External
Eurofins · Boston, MA$104K–$112K/yrFull-timeOn-site1w ago
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Responsibilities
- Lead genomic safety assessment packages, including off-target discovery, verification, validation, and genomic integrity characterization
- Apply and evaluate off-target discovery approaches using: In silico tools (e.g., CALITAS, CRISPRme, Cas-OFFinder)
- Biochemical methods (e.g., SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq)
- Cell-based assays (e.g., GUIDE-seq, INDUCE-seq)
- Drive off-target confirmation using sequencing-based approaches such as AmpSeq, rhAmpSeq, and hybrid capture
- Assess genomic integrity using orthogonal platforms including karyotyping, optical genome mapping, and whole genome sequencing (WGS)
- Evaluate genotoxicity risks associated with next-generation genome editing technologies, including base and prime editing
- Support and/or lead development of novel assays for emerging genome editing modalities (Gen 5+)
- Integrate biodistribution data to inform tissue selection for off-target verification studies
- Collaborate cross-functionally and present findings clearly to scientific and project teams
Requirements
- B.S. with 5+ years, M.S. with 3-7 years, or Ph.D. with 2-4 years of industry experience in genomics, molecular biology, biochemistry, or a related field
- Hands-on experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics
- Strong working knowledge of CRISPR-based genome editing technologies
- Experience with next-generation sequencing workflows and data interpretation
- Familiarity with base editing, prime editing, and associated genotoxicity considerations
- Demonstrated scientific problem-solving skills; assay development experience is a plus
- Strong communication skills with the ability to present complex data to diverse audiences
- Self-motivated, adaptable, and able to work both independently and collaboratively
- Experience with optical genome mapping (e.g., Bionano platform)
- Understanding of regulatory expectations for genomic safety (IND/BLA submissions)
- Exposure to human diversity-informed off-target methods (e.g., ONE-seq)
- Authorization to work in the U.S. without sponsorship
- The position is Full Time, Monday-Friday, 8 am-5 pm. Candidates currently living within a commutable distance of Boston, MA, are encouraged to apply
- What to Exp ect in the Hiring Process:
- 10-15 Minute Phone Interview with Regional Recruiter
- 45-60 Minute Virtual Interview with Manager and/or Group Leader
- 45-60 Minute In-Person Meeting for a Casual Discussion of the Role
Benefits
Excellent full-time benefits, including comprehensive medical coverage, dental, and vision optionsLife and disability insurance401(k) with company matchPaid vacation and holidaysYearly goal-based bonus & eligibility for merit-based increasesAnnual Compensation is $104,000 - $112,320, depending on education and experienceEurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.Dental insuranceVision insurance401(k)Paid time offPerformance bonus
Additional Information
We are seeking a Scientist - Off-Target Genomics (Gene Therapy) to lead and execute genomic safety assessment strategies for gene editing therapeutics. This role focuses on evaluating off-target effects, genomic integrity, and emerging genome editing modalities.
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