Research Associate II, CRISPR-X - LNP

Responsibilities

• Design, optimize, characterize, and execute lipid nanoparticle (LNP) formulations across a diverse range of lipid compositions and therapeutic payloads with minimal supervision.
• Apply hands-on expertise in LNP analytical characterization techniques, including RiboGreen assays, DLS, NanoFCM, NTA, TFF, endotoxin testing, and HPLC, as well as molecular biology methods such as DNA/RNA extraction, ELISA, SDS-PAGE, PCR, and Western blotting.
• Generate high-quality, reproducible datasets and maintain accurate, detailed experimental documentation in electronic laboratory notebooks (ELNs).
• Contribute to platform innovation by investigating LNP mechanisms of action to improve delivery efficiency, therapeutic potency, and formulation stability.
• Present experimental results, technical findings, and project updates to cross-functional teams and broader organizational audiences.
• Effectively manage multiple priorities and projects in a fast-paced, highly collaborative research environment.

Requirements

• BS or MS in Chemistry, Chemical Engineering, Biochemistry, or a related scientific discipline.
• Relevant industry or academic research experience: Research Associate II: 2-5+ years with a bachelor's degree or 0-2+ years of relevant experience with a master's degree
• Hands-on experience in lipid nanoparticle (LNP) formulation and analytical characterization for nucleic acid and targeted delivery applications.
• Strong understanding of drug delivery systems and gene editing therapeutics.
• Demonstrated ability to work independently while contributing effectively within a fast-paced, results-driven, and collaborative research environment.
• Highly organized with strong scientific rigor, problem-solving skills, and attention to detail.
• Experience with high-throughput formulation screening and knowledge of microfluidic mixing process.
• Prior experience of ionizable lipid design, bioconjugation, and process development preferred.
• Prior experience with scale-up and large-scale manufacturability development of LNPs.
• Understanding of RNA engineering, molecular biology, and hands-on experience of maintaining cells and performing in vitro transfection.
• Competencies
• Collaborative - Openness, One Team
• Undaunted - Fearless, Can-do attitude
• Results Orientation - Delivering progress t

Benefits

Additional Information

Job Description: Company Overview Founded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY ® (exagamglogene autotemcel [exa-cel]), the world's first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependent beta thalassemia. CRISPR Therapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics has established strategic collaborations with leading biopharmaceutical partners, including Vertex Pharmaceuticals . CRISPR Therapeutics AG is headquartered in Zug, Switzerland , with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California. Position Summary We are seeking a highly motivated Research Associate II to support the design, development, and optimization of novel lipid nanoparticle (LNP) formulations to advance our non-viral delivery platform for hepatic and extra-hepatic tissues, and enable next-generation genome editing therapies from discovery through clinical translation. The ideal candidate will bring hands-on expertise in LNP formulation development, scale-up, analytical characterization, chemistry, and process development, with a strong passion for innovation in nucleic acid delivery technologies. This individual will join the dynamic, fast-growing, and highly collaborative CRISPR-X division and contribute to both platform technology innovation and preclinical therapeutic programs. In this role, the candidate will work cross-functionally to develop and characterize advanced delivery systems for emerging editing modalities, helping drive transformative gene editing therapies toward patients with unmet medical needs.

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