Raven StealthCo- Director, Oligonucleotide and Conjugation Chemistry

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About Raven: We are Raven, RA Capital's healthcare incubator. From discovery to delivery, whether we incubate, accelerate or rejuvenate, Raven's goal is to turn scientific breakthroughs into transformative therapies and get them quickly, safely and efficiently to the patients that need them most. Raven's experienced scientists, operators, and healthcare innovators have deep sector expertise across therapeutics, diagnostics, devices and services. They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you. About RA Capital: Founded in 2004, RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies. RA Capital creates and funds innovative companies, from private seed rounds to public follow-on financings, allowing management teams to drive value creation from inception through commercialization and beyond. RA Capital's knowledge engine is guided by our Tech Atlas internal research division, and Raven, RA Capital's company building team, offers entrepreneurs and innovators a collaborative and comprehensive platform to explore the novel and the re-imagined. RA Capital has more than 150 employees and over $10 billion in assets under management. Company Background We are a well-funded, stealth-mode biotechnology company developing next-generation oligonucleotide-based therapeutics for a high-value disease area with significant unmet medical need. The company is headquartered in Cambridge, Massachusetts, and was incubated and funded by a leading life sciences venture group. We are led by an experienced founder-CEO with a strong track record of building and scaling biotechnology companies. The company has completed a robust incubation process and is backed by a substantial seed investment. Our disease focus represents a large, multi-billion-dollar market with significant room for improvement over existing therapies. We are building a first-of-its-kind integrated platform leveraging tailored oligonucleotide chemistry, targeted delivery, and state-of-the-art analytics to develop first-in-class and best-in-class therapeutics. The company is currently operating in stealth mode as we commit to building and scaling quickly to create transformational medicines with significant market potential. Our platform is designed to address multiple disease indications at scale, including both primary and adjacent therapeutic areas. Opportunity The company is in the discovery stage and will invest heavily in its emerging platform for oligonucleotide delivery. Our disease focus offers strong translatability from animal models to humans, which provides a potentially rapid and efficient path to the clinic. Given the company's recent funding and commitment to building a first-in-class platform with clear therapeutic targets and indications, we are recruiting a Director, Oligonucleotide and Conjugation Chemistry. This individual will be responsible for implementing chemical technologies to develop oligonucleotides and conjugates for our targeted delivery platform. The Position The Director, Oligonucleotide and Conjugation Chemistry will report directly to the VP of Delivery and will interface frequently with company leadership and cross-functional teams to advance oligonucleotide therapeutic programs. This individual will contribute to strategy and execution of discovering novel delivery systems and will manage chemistry resources to prepare oligonucleotide conjugates. This individual will be expected to interact frequently with external CROs as well as recruit, mentor, and manage a skilled scientific team under their leadership. Specific responsibilities: Oversee chemistry aspects of the development of oligonucleotide conjugates for biological evaluation in our targeted delivery platform Manage external chemical synthesis activities which may include oligonucleotide synthesis; small-molecule, lipid, and peptide ligand synthesis; linker synthesis; and oligonucleotide-conjugate synthesis Build internal lab capabilities and lead a team of conjugation and analytical scientists to prepare, purify, and analytically characterize oligonucleotide conjugates, particularly antibody-oligonucleotide conjugates Work cross-functionally with protein engineers and biologists to ensure timely and adequate preparation of oligonucleotide conjugates for biological evaluation as well as to contribute to the design of in vitro and in vivo studies Contribute to intellectual property around the design of oligonucleotides and oligonucleotide conjugates for the company Work closely with company leadership, contributing to scientific strategy and assisting in preparing materials (data reviews, presentation decks) for internal and external constituents; participate in external

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