Director, US Medical Affairs Strategic Operations

About the role

The Director of US Medical Affairs Operations will be instrumental in enabling medical impact through operational leadership, strategic planning, process and systems enablement across the full product lifecycle and portfolio. Reporting to the VP, Medical Affairs, this highly visible role drives planning, integration, execution, and governance of medical affairs activities across the US Medical Affairs portfolio. As a core member of the USMA Leadership Team, this role ensures that strategy is translated into coordinated, high-impact execution across US cross-functional stakeholders. This role will collaborate across internal teams and external partners to deliver compliant, efficient, and scalable solutions that support medical strategy, launch readiness, and scientific exchange in the US Region. Key responsibilities include: Strategic Operations Leadership & Execution Management Translate Medical Affairs strategy into aligned goals and cross-functional plans spanning scientific engagement, communications, evidence generation, and launch readiness; enable alignment between US and Global strategies and drive clarity on priorities and execution. Partner with the Head of US Medical Affairs, Global Medical Affairs, Global Commercialization, US Commercial and Market Access, Regulatory and Clinical Development stakeholders to ensure strategic alignment and coordinated execution. Led complex, cross-functional medical workstreams spanning launch readiness, scientific communications, congress strategy, HEOR/IEP coordination, and external engagement strategy for new product launches, indication expansions, and lifecycle management. Establish a clear operating rhythm to facilitate strategic planning, budgeting, and business reviews and align with enterprise and global strategic planning efforts. Serve as trusted advisor to VP and US Medical Affairs Leadership by synthesizing complex clinical, scientific and market insights into actional recommendations to enable timely decision making, prioritization, planning, and resourcing of US Medical Affairs priorities. Medical Governance & Compliance and Organizational Enablement Evolve US Medical Affairs governance frameworks, including Medical Review Committees (MRC), and US Medical Asset Teams (US MATs) & assess how to effectively coordinate acros various enterprise forums (as needed) as the portfolio grows. Partner with Regulatory and Compliance to ensure compliance with US regulatory standards (FDA, GVP, PhRMA Code), internal policies, and legal requirements. Establish and maintain SOPs, training, and internal education to build operational excellence and capabilities across Medical Affairs. Serve as a Medical Affairs representative for inspection readiness and audit support, providing training, documentation, and cross-functional coordination. US Region representation & leadership across Medical Operations Excellence Build strong relationships with Global Medical Affairs Operational Excellence and partner with US Medical Field Operations Manager to synergize efforts and evolve grant and funding, congress, ad board and publications planning and execution to meet US Region needs. Systems, Tools, and Digital Enablement Champion continuous innovation in US Medical Affairs operations, advance new ways of working including AI-enabled insights and data-drive planning to drive simplification, scalability and improved decision Medical Affairs processes. Collaborate on implementation and governance of digital platforms for insights management, medical planning, and content review. Required Skills, Experience and Education: Bachelor's (BS) degree required; advanced degree (MS, MBA, PharmD, PhD) or PMP certification strongly preferred. 15+ years of experience in biotechnology or pharmaceutical industry (with BS), 13+ years (with MS) or 11+ years (with PharmD/PhD), including 8+ years in Medical Affairs or biotechnology project or program management roles. Experience working in the Medical Affairs function, including scientific communications, external engagement, medical congresses, medical compliance, and data dissemination. Experience creating strong partnerships across Medical, Commercial, Regulat

Additional Information

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

Your Match

How well this role fits your profile.

Company Intel

What employees say

Worked at revolutionmedicines? Share your experience