Graduate Student- Mancias Lab

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The Mancias Lab studies critical aspects of the biology of pancreatic cancer to develop novel therapeutic approaches. Areas of emphasis are on the role of selective autophagy and iron metabolism in pancreatic cancer molecular pathogenesis (Mancias et al., Nature 2014; Mancias et al., eLife 2015; Santana-Codina et al., Cancer Discovery 2022, Hoelzgen, Nguyen et al. Nature Communications 2024). We are also interested in identifying the biochemical pathways and signaling networks that mediate pancreatic cancer treatment resistance, including to targeted inhibitors (e.g. oncogenic KRAS inhibitors, immunotherapy and radiotherapy (Biancur et al., Nature Communications 2017; Santana-Codina et al., Cell Reports 2020, Zhang et al. Nature Communications 2025). The lab takes a comprehensive approach to study our questions combining biochemical, quantitative mass spectrometry-based proteomics, CRISPR genetic screens (in vitro and in vivo), cell biological, and mouse modeling techniques. This individual will be an important member of our research team and will be involved in assisting research projects utilizing several techniques that are fundamental to the workflow of the Mancias Lab. In addition to the bench-based research, responsibilities will also include some aspects of laboratory management and organization. Training is available in all aspects of experimental research. For more information on the lab, please visit here: https://manciaslab.dana-farber.org/ and here: https://twitter.com/ManciasLab Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Mackenzie will be evaluating the hypothesis that KRAS inhibition induces lipid peroxides in pancreatic cancer that increases sensitivity to ferroptosis. She will evaluate combination efficacy of KRAS inhibition and ferroptosis induction and the mechanisms underlying this increased sensitivity to ferroptosis. At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEO Poster . Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA). $41,200.00 - $49,600.00

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