Medical Director, Medical Affairs

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About Beeline Medicines: Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients - realizing a world where people with immune-mediated diseases can live life fully. Job Summary: The Medical Director, Medical Affairs is a senior therapeutic and disease area expert who serves as the organization's primary external medical and scientific expert for healthcare providers (HCPs), key medical experts (KMEs), clinical investigators (together with development and patient advocacy organizations. This role operates at the intersection of scientific leadership and external engagement - building and sustaining trusted peer-level relationships within the I&I community while driving the development and execution of the organization's medical affairs strategy for its assigned program strategy in lupus and broader I&I portfolio. The Director leads scientific exchange, supports evidence generation, shapes medical education and KME engagement programs, and serves as a senior internal scientific authority - providing medical input to clinical development, commercial readiness, market access, and regulatory strategy. Reporting to the Executive Director, Medical Affairs, this individual brings deep scientific expertise in autoimmune disease, strong KME relationship management, and the strategic leadership presence required to drive the medical affairs function forward in a clinical-stage, resource-efficient biotech environment. Work Arrangement & Location: Hybrid - This position follows a hybrid work schedule, requiring a minimum of two (2) days on-site per week - currently designated as Tuesday and Wednesday . Additional on-site days may be required based on business needs, team priorities, or leadership direction. Essential Duties and Responsibilities: Serve as the primary medical and scientific point of contact for KMEs, HCPs-, and patient advocacy groups within the I&I therapeutic area - with a primary focus on lupus (SLE and/or CLE), rheumatology, and dermatology - building and sustaining trusted, peer-level relationships that advance the organization's scientific and medical objectives. Define and lead the execution of the medical affairs strategy for the I&I pipeline, including lupus indications - encompassing KME engagement, evidence generation, medical education, advisory board programming, and publication support - in alignment with clinical development Lead and conduct peer-to-peer scientific exchange with KMEs, investigators, and HCPs together with the development team- sharing clinical and emerging data, discussing unmet medical needs, and gathering external insights (such as in depth knowledge of the patient journey from diagnosis to treatment along with barriers that are encountered along the way) that inform medical strategy, pipeline positioning, and commercial readiness. Monitor and critically assess competitive clinical data and emerging mechanisms to inform differentiation and scientific positioning. Lead the design and execution of medical advisory board meetings - identifying and engaging the right scientific experts, developing scientifically rigorous agendas, and ensuring that advisory board insights translate into actionable medical and strategic recommendations. Oversee the development and review of medical content - including medical education materials, scientific slide decks, congress abstracts, posters, and manuscripts - ensuring scientific accuracy, regulatory compliance, and strategic alignment across all external communications. Lead scientific engagement strategy for major rheumatology congresses, including KME interactions, data communication planning, and insight capture. Partner with Field Medical Affairs and MSL teams to ensure accurate, balanced, and up-to-date scientific tools and resources are available and consistently applied in field engagements - participating directly in key field interactions when the scientific complexity or stakeholder importance warrants senior medical presence. Provide strategic medical input into clinical development programs, partnering with development discussing trial design considerations (e.g., endpoints, patient selection, biomarkers), data interpretation, and differentiation versus emerging therapies. Collaborate with Clinical Development, Biostatistics, Regulatory Affairs, and

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