Director, Translational Science (Neurology)

Responsibilities

• Translational Strategy & Execution
• Contribute to and drive execution of translational strategies across neurology programs
• Design and implement multi-modal biomarker approaches (e.g., biofluid, imaging, digital biomarkers)
• Help define data-driven decision frameworks in collaboration with translational and clinical leadership
• Translate emerging disease biology into testable clinical hypotheses and biomarker strategies
• Clinical & Scientific Integration
• Lead translational components of programs from study design through data analysis and interpretation
• Interpret and contextualize biomarker and clinical data to inform program decisions and development strategy
• Partner with Clinical, Clinical Pharmacology, and Biostatistics teams to support trial design, dose strategy, and endpoint selection
• Bridge preclinical findings and clinical development through mechanistic and disease-relevant insights
• Biomarker Development & Data Insights
• Contribute to development and implementation of biomarker strategies supporting clinical trials
• Work closely with internal teams and external partners to ensure robust biomarker performance and data quality
• Collaborate with data scientists to integrate datasets and deliver actionable insights from complex, multimodal data
• Collaboration & Scientific Leadership
• Serve as a key translational representative on cross-functional program teams
• Influence program direction through scientific insight and data-driven recommendations
• Act as a scientific thought partner within the team and contribute to capability building
• Present findings internally and externally; contribute to scientific publications and congress presentations
• May mentor junior scientists or contribute to development of team expertise
• Innovation & External Engagement
• Engage with academic and industry experts to stay at the forefront of emerging science in neurodegenerative diseases
• Apply innovative approaches (e.g., omics, AI/ML, digital biomarkers) to better understand disease heterogeneity and progression
• Integrate multimodal data to refine disease models, patient stratification approaches, and biomarker strategies
• Regulatory Contributions
• Contribute to translational aspects of regulatory documents and submissions (e.g., protocols, investigator brochures, briefing materials)
• Partner with senior leaders to support Health Authority interactions and strategy
• Support development of companion diagnostic and biomarker qualification strategies

Requirements

• PhD, MD, or equivalent in Neuroscience, Pharmacology, Molecular Biology, or related field
• ~8-10 years of relevant experience in pharmaceutical/biotechnology drug development
• Strong expertise in translational science and biomarker development
• Demonstrated experience supporting translational aspects of clinical programs
• Hands-on experience with biomarkers (fluid, imaging, and/or digital)
• Preferred Scientific Expertise
• Deep expertise in one or more non-Alzheimer's neurodegenerative diseases, including: Parkinson's disease
• Lewy body dementia
• Primary tauopathies (e.g., PSP, CBD)
• Experience with disease-relevant biomarkers (e.g., α-synuclein, tau, sleep/circadian measures) strongly preferred
• Familiarity with clinical endpoints and disease progression in relevant indications
• Core Capabilities
• Strong ability to interpret complex biological and clinical data and translate into actionable insights
• Proven ability to collaborate and influence within cross-functional teams
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Benefits

Additional Information

At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai's human health care (hhc) mission. We're a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer's disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you. Director, Translational Science (Neurology) Position Summary The Director of Translational Science is a scientifically driven leader who contributes to and drives the execution of integrated translational strategies across neurology programs spanning discovery through early clinical development. This role focuses on enabling data-driven decision-making by linking disease biology, biomarkers, and clinical outcomes. This position is designed to complement existing expertise in Alzheimer's disease by bringing deep knowledge in non-Alzheimer's neurodegenerative disorders, including Parkinson's disease, Lewy body dementia, primary tauopathies, and sleep-related neurobiology. The successful candidate will combine strong scientific insight with hands-on engagement in biomarker strategy, data interpretation, and cross-functional collaboration.

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