Senior Scientist, Computational Biology

Requirements

• Ph.D. in Computational Biology, Bioinformatics, Genomics, Computational Chemistry, or a related quantitative discipline, with 3+ years of post-PhD experience in a biotech or pharmaceutical industry setting . Academic-only or pure-tech industry experience will not be considered for this role.
• Demonstrated track record of shipped, decision-impacting analyses on industry programs - e.g., target validation, biomarker discovery, oligonucleotide or small-molecule pharmacology, or preclinical-to-clinical translation.
• Strong scientific programming in R and/or Python, with proficiency in standard biological data analysis libraries (Bioconductor, tidyverse, pandas, numpy, scikit-learn, etc.).
• Solid experience analyzing NGS data, including RNA-seq differential expression workflows, variant calling, and quality control of sequencing experiments.
• Familiarity with oligonucleotide or RNA-based therapeutics - including chemical modifications, delivery modalities (GalNAc, LNP), and the analytical considerations specific to ASOs, siRNAs, or related modalities.
• Working knowledge of statistical modeling appropriate to biological data: linear and generalized linear models, mixed-effects models, multiple testing correction, and basic experimental design.
• Comfort working with messy, real-world experimental data and collaborating directly with bench scientists to refine analytical questions.
• Excellent written and oral communication skills, including the ability to translate technical results for non-computational stakeholders.

Additional Information

Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body's natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro is based in Cambridge, Massachusetts. We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health. Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.

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