Biochemistry Research Associate - Structural Biology (Gene-to-Structure) - CDI- M/F

Responsibilities

• Design protein constructs for structural/functional characterization purposes
• Generate vectors for heterologous recombinant protein expression in bacteria, insect- and/or mammalian cell hosts.
• Develop and optimize methods for protein extraction, purification, characterization and quantification with a high level of independent critical thinking.
• Propose strategies to enable structural characterization of drug targets and their ligands.
• Prepare biological samples for structure elucidation, including isotope labelling, purification crystallization trials and grid clipping. Coordinate sample transfer and remotely supervise structural analysis at partner laboratories.
• Analyze and process structural data to generate accurate models.
• Ensure high-quality data generation, analysis, and timely report to project teams.
• Properly document experimental design, findings, and protocols and comply with all laboratory training and safety requirements.
• Collaborate with multi-disciplinary project teams and communicate scientific/technical contributions to deliver on project goals in relevant meetings.
• Establish relationships and coordinate collaborations with vendors, external partners and CROs to achieve high standards of productivity and quality, extend internal capabilities and optimally serve project needs.
• Drive scientific and technical innovations to develop and enhance functional capabilities.
• We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation, very attractive CE...
• Who you are ?
• Your skills at the service of innovative projects:
• Qualifications, Experience and Skills
• MSc in Biochemistry, Biophysics or related field with 5+ years' experience in a biotech/pharmaceutical setting (or recent Ph.D. with relevant exposure to drug discovery).
• Demonstrated hands-on proficiency with heterologous protein expression systems, and protein extraction and purification methods (e.g. chemical and mechanical cell lysis, ultracentrifugation, dialysis, batch- and liquid chromatography).
• Command of several low- and high-resolution structural biology methods (e.g. analytical ultracentrifugation, CD, SEC-MALS, DLS, X-ray crystallography, NMR, Cryo EM, HDX-MS).
• Working knowledge of adjacent disciplines for the characterization of enzyme activities, protein-protein and protein-ligand interactions is a plus.
• Proficiency with relevant data processing analysis and visualization software tools.
• Experience in oncology is a plus.
• Motivated and agile team player with the ability to work in a collaborative environment across the R&D organization.
• Excellent verbal, and written communication skills in English are essential.
• At Pierre Fabre Laboratories, we believe that our greatest asset is our people.

Benefits

Additional Information

Who we are ? We are Pierre Fabre Laboratories, a global leader combining pharmaceutical expertise with dermo-cosmetics to support consumers and patients at every stage of their care journey. Our portfolio includes several medical franchises and international brands such as Eau Thermale Avène, Ducray, A-Derma, Klorane, René Furterer, and Pierre Fabre Oral Care. By joining us, you become part of a meaningful company where the human dimension is essential. You become a participant in the "We Care Movement," a movement that values excellence and innovation within passionate teams. Together, we push the boundaries of science to unite health and beauty for the benefit of all, because Every time we care for a single person, we make the whole world better. Present in 120 countries with a team of over 10,000 employees, we are proud to create a scientific and human impact, today and tomorrow! If caring is at the heart of your values, join Pierre Fabre Laboratories and become a key player in the "We Care Movement". Your mission We are seeking for a talented and highly motivated Biochemistry Research Associate to join our Oncology Drug Discovery team and support our small molecule/antibody identification and characterization efforts. The ideal candidate will have relevant experience in the pharmaceutical / biotech industry, with sound hands-on expertise conducting high-resolution structural analysis of biological macromolecules with state-of-the-art bioinformatics, protein biochemistry, biophysics and structural biology techniques. This position is a lab-based and attached to our Oncopôle site in Toulouse, France. Your role within a pioneering company in full expansion:

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