Head of DMPK

Responsibilities

• In Vitro ADME
• Provide strategic oversight of in vitro ADME activities including metabolic stability, CYP inhibition/induction, plasma protein binding, permeability (Caco-2/MDCK), solubility, and transporter assays.
• Define and champion in vitro-in vivo correlation (IVIVC) strategies across programs to inform candidate selection and advance structure-activity/property relationships.
• Lead interpretation of metabolic soft spot and MetID data, integrating findings into actionable guidance for medicinal chemistry teams.
• Establish and manage CRO partnerships for outsourced ADME studies, including vendor qualification, scientific oversight, and data quality assurance.
• Bioanalytical Sciences
• Own or oversee bioanalytical strategy for the portfolio, including LC-MS/MS method development and validation for small molecules and their metabolites across biological matrices.
• Ensure GLP-compliant bioanalytical practices for IND-enabling studies; manage regulated bioanalysis timelines and data quality through CRO partners.
• Evaluate and deploy fit-for-purpose bioanalytical approaches for induced proximity molecules, including strategies for quantifying bifunctional compounds and target engagement biomarkers.
• In Vivo Pharmacokinetics
• Oversee and provide strategic direction for in vivo PK studies across rodent and non-rodent species, including study design, data interpretation, and cross-program learnings.
• Ensure high-quality PK data analysis (NCA and compartmental) using Phoenix WinNonlin or equivalent, setting standards for reporting and data integrity.
• Integrate PK data with pharmacology and toxicology readouts at a program level to shape candidate progression criteria and target product profiles.
• Manage and develop CRO relationships for in vivo studies, negotiati

Benefits

Additional Information

tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate DMPK expert to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Head of DMPK to lead and shape our drug metabolism and pharmacokinetics function. This is a high-impact leadership role in which you will own the DMPK strategy across our small molecule portfolio, build and mentor a growing team, and serve as the primary DMPK voice in cross-functional and external settings. You will set scientific direction, drive regulatory strategy, and play a pivotal role in advancing programs from lead optimization through IND and into clinical development. You will work closely with our medicinal chemistry, structural biology, pharmacology, and toxicology teams to translate DMPK science into actionable program decisions. The ideal candidate is a hands-on scientific leader who combines deep technical expertise in ADME, in vivo PK, and PK/PD modeling with the ability to build and inspire a high-performing team. This role is ideal for someone who has led DMPK at a pharma or biotech and now wants to build the function from the ground up at a mission-driven company working at the frontier of induced proximity medicine. Critically, this role demands familiarity with the unique DMPK challenges of induced proximity medicines and bifunctional molecules. These include non-linear and dose-dependent pharmacokinetics arising from ternary complex formation, linker and warhead metabolic soft spots, high molecular weight and physicochemical complexity affecting permeability and oral bioavailability, tissue distribution considerations for proteasome-engaging degraders, and the interpretation of hook-effect phenomena in in vitro and in vivo settings. Experience in TPD, molecular glue, PROTAC, or other bifunctional modality DMPK is a meaningful differentiator for this role. This is an on-site position with flexible working hours.

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