Director/Senior Director, Drug Metabolism & Pharmacokinetics (DMPK)

Requirements

• Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or related discipline
• 12+ years of industry experience in DMPK within biotech or pharmaceutical settings
• Demonstrated success advancing small molecule programs from discovery through IND
• Deep expertise in ADME, human PK simulations, PK/PD modeling, and translational science
• Experience working in or with early-stage companies, with comfort operating in resource-constrained, fast-paced environments
• Strong track record of managing external CROs and consultants, and delivering high-quality data
• Excellent communication skills, with the ability to influence cross-functional teams and leadership

Additional Information

Company Overview At Renasant Bio, we are driven by a simple goal: to change what's possible for patients with kidney disease. ADPKD remains one of the most challenging areas in medicine, and we believe it requires bold thinking, rigorous science, and a team committed to doing things differently. We're looking for individuals who bring both scientific rigor and creativity to hard problems, and who believe great work is built through respectful, direct collaboration. You communicate with honesty and transparency, adapt quickly as priorities evolve, and hold yourself-and others-to a high standard. Above all, you operate with urgency and purpose, grounded in the knowledge that patients are waiting. Based at Bakar Labs in Berkeley, CA with additional support in Cambridge, MA, we are advancing new therapies designed to make a meaningful difference for patients. Job Summary We are seeking a strategic, hands-on Director/Senior Director of Drug Metabolism & Pharmacokinetics (DMPK) to lead the design and execution of DMPK strategies across our small molecule discovery and development programs. This role is primarily focused on enabling high-quality decision-making across the portfolio: driving DMPK strategy from early discovery through human POC studies, guiding compound optimization, and ensuring robust characterization of pharmacokinetics, metabolism, and exposure-response relationships. In addition to core scientific leadership, this individual will play a critical role in shaping program strategy, working closely with medicinal chemistry, biology, and external partners to integrate DMPK insights into broader project decisions. As Renasant rapidly advances its pipeline, this role will be instrumental in supporting the company's goal of bringing multiple drug candidates into the clinic. This is an excellent opportunity for someone who thrives in a fast-paced, early-stage environment and is excited to build and scale DMPK capabilities while influencing the trajectory of multiple programs. This role is approximately 60-70% strategic scientific leadership and 30-40% hands-on execution and external oversight, with the opportunity to expand scope as the pipeline grows. This is a hybrid position based in either Berkeley, CA or Cambridge, MA, requiring at least three days per week onsite.

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