Senior Scientist, siRNA Analytical Development

Responsibilities

• Develop and optimize analytical methods for the characterization of siRNA and oligonucleotide compounds, including HPLC, IEX-HPLC, IP-RP-HPLC, LC-MS, and UV/fluorescence spectroscopy.
• Perform purity assessment, identity confirmation, quantification, and impurity profiling of siRNA and modified oligonucleotide materials.
• Develop and implement analytical strategies for novel siRNA modifications, conjugates (e.g., antibody-siRNA conjugates), and delivery formats.
• Generate, review, and interpret analytical data with a high level of rigor, ensuring data integrity and compliance with internal quality standards.
• Maintain thorough laboratory documentation including experimental records, SOPs, and analytical reports.
• Partner with cross-functional teams including siRNA synthesis, the antibody conjugation group, screening, and CMC to support platform and project objectives.
• Monitor emerging analytical technologies and best practices in oligonucleotide characterization and RNA-based therapeutics.
• Contribute to a collaborative, innovative team environment and present scientific data to internal stakeholders.
• BS, MS, or PhD in Chemistry, Chemical Biology, Biochemistry, or a related field with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
• Hands-on experience with analytical characterization of siRNA, ASO, or related modalities.
• Strong proficiency in HPLC techniques (RP-HPLC, IEX, IP-RP), LC-MS, and UV spectroscopy for oligonucleotide analysis.
• Experience with data analysis software for chromatographic and mass spectrometric data.
• Solid understanding of RNA chemistry, oligonucleotide modifications, conjugation chemistry, and associated analytical challenges.
• Demonstrated ability to independently troubleshoot complex analytical problems and drive continuous method improvement.
• Strong attention to detail, organizational skills, and commitment to data quality and integrity.
• Excellent written and verbal communication skills; ability to present scientific findings to internal teams.
• Position will be filled at level commensurate with extent of education, experience, and accomplishment - Senior Scientist I or Senior Scientist II
• Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• This job may be eligible to participate in our long-term incentive plan.
• AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
• US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
• US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
• https://www.abbvie.com/join-us/reasonable-accommodations.html

Benefits

Additional Information

The Biotherapeutic and Genetic Medicine (BGM) department at AbbVie is seeking a highly motivated Senior Scientist to join the growing siRNA platform team. In this role, you will work closely with the siRNA synthesis team and cross-functional partners to develop, optimize, and execute analytical methods for the characterization of siRNA and oligonucleotide therapeutics. This individual will serve as the analytical subject matter expert on the siRNA platform, ensuring the delivery of high-quality, well-characterized siRNA materials in support of genetic medicine programs.

Your Match

How well this role fits your profile.

Company Intel

What employees say

Worked at Abbvie? Share your experience