Sr. Software Engineer

About the role

About Karius Karius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Position Summary: We are building and operating a unique software stack of cloud infrastructure, software services, APIs, web and mobile interactive interfaces, and AI-driven data analytics pipelines to deliver life-saving results in the highly complex infectious disease landscape. We believe the success of Karius' products is driven by both our unique technology and the elegance of the software solution. We seek talented and passionate individuals who want to be part of this impactful journey reaching the team's ambitious goals, far beyond what any single individual could accomplish. Duration: This is a temporary/contract position up to 6 months. Why Should You Join Us? Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale. Reports to: Sr. Director, Engineering Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities Understand user needs and objectives by collaborating closely with cross-functional groups across Karius, including Engineering, Software Products, Analytics, Lab Operations, and other business partners. Develop and share software subsystem designs that address user needs and enable teams to achieve their objectives. Lead the implementation and end-to-end testing of software solutions and components, including driving user acceptance. Own software subsystems, API sets, or user applications, serving as the go-to subject matter expert for assigned areas. Develop strong expertise in the corresponding business domain to ensure software solutions are aligned with operational and user needs. Contribute to the continuous improvement of the engineering lifecycle by leading enhancements to tools, processes, and ways of working. Help advance a high-performing engineering culture through close collaboration, engagement, and partnership with the broader engineering team to solve technical challenges as they arise. What's Fun About the Job? Karius is operating at the edge of what is now known to be possible in diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: No travel required. Physical Requirements Subject to extended periods of sitting and/or standing, vision to monitor and moderate noise levels. Work is generally performed in an office, lab or clinical environment. Position Requirements BS or MS degree in Computer Science, Software Engineering, Electrical Engineering, Bioengineering, or a related technical field involving algorithms or coding, such as physics or mathematics 5+ years of software engineering experience designing, developing, and maintaining full-stack solutions in a production environment Advanced knowledge and 3+ years of experience implementing production software using TypeScript Strong TypeScript and Node.js engineering experience, including building and maintaining substantial TypeScript services in production Experience designing and operating microservices-based systems, with a clear understanding of service boundaries, contract evolution, error handling across service calls, and observability Production experience with Kafka or a comparable event-streaming platform, including topic design, partition strategy, consumer group behavior, idempotency, ordering guarantees, and handling delayed, failed, or unprocessable messages; Confluent experience is a plus Experience designing PostgreSQL database schemas, with a strong understanding of transactions, indexing, and

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