Postdoctoral Research Associate

About the role

As one of the fastest-growing academic health centers in the nation, Texas A&M Health encompasses five colleges and numerous centers and institutes working together to improve health through transformative education, innovative research and team-based health care delivery. What we want The Postdoctoral Research Associate will be involved in the identification of epigenetic and immunoepigenetic combination treatments that upregulate the MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy. The position will support translational cancer prevention studies using cell-based systems, primary cultures, 3D spheroid/organoid models, molecular assays, immunological assays, and rodent tumor models What you need to know Salary: W ill be commensurate based on the selected hire's education and experience . Location/Schedule: Houston, TX/Full-Time Apply! Submitting a cover letter, CV/Resume to assist us with the review process. You may upload these documents on the application under CV/Resume. Required Education and Experience MD/PhD in biochemistry, cell biology, immunology, cancer biology, pharmacology, molecular biology, or a related biomedical science field.

Responsibilities

• Transcriptional and epigenetic regulation of MHC
• Identification of epigenetic and immunoepigenetic combination treatments that upregulate MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy.
• Studies may include HDAC-related mechanisms, immunoproteasome regulation, antigen-presentation pathways, and immune-response biomarkers.
• Molecular, cellular, and biochemical work
• Design and execute experiments involving epigenetic analyses, immunological assays, and molecular biology, protein biochemistry, and cancer prevention models.
• Rodent work and preclinical tumor models
• Conduct rodent studies according to approved protocols and the highest ethical standards.
• Participate in breeding and genotyping. Carefully monitor and record rodent well-being and morbidity.
• Perform endoscopies and polypectomies on live rodents.
• Perform necropsies and collection of organs for H&E, molecular, and immunohistochemical work.
• Administer drugs/compounds to study animals via intra-oral, intra-venous, intra-peritoneal or subcutaneous routes.
• Collaborations & presentations
• Participate actively in weekly lab meetings within the center, and with other internal and external collaborators.
• Participate in joint projects involving faculty, postdoctoral fellows, students, technicians, and core facility pers

Requirements

• Experience with cancer biology, molecular biology, cell culture, and animal cancer models.
• MD/PhD with experience in translational cancer biology, cancer prevention, immunology, epigenetics, or related biomedical research. Animal cancer models, primary tissue culture, 3D spheroid/organoid cultures, molecular biology, protein biochemistry, and immunology assays.
• Epigenetics, HDAC biology, host immune surveillance, antigen-presentation pathways, immunoproteosome assays, with technical expertise of FACS, RNA-seq, Co-IP, ChIP, and T-cell co-culture systems.
• Experience in performing rodent tumor studies under approved IACUC protocols, including oral gavage, intra-venous, intra-peritoneal and subcutaneous injections
• Experience with antibody development, hybridoma screening, ELISA-based assays, and antibody characterization.
• Clinical or translational research background, including MD training or experience connecting preclinical findings to human disease relevance, is preferred.
• Knowledge, Skills, and Abilities
• Ability to multi-task and work cooperatively with others.
• Must be literate in the English language and be able to comprehend and follow effectively both written and verbal instructions.
• Excellent interpersonal, oral and written communication skills in English.
• Ability to do independent research in areas related to cancer immunology and epigenetics.
• Ability to maintain accurate records, analyze data, prepare figures and reports, and contribute to manuscripts and presentations.

Benefits

Additional Information

Job Title Postdoctoral Research Associate Agency Texas A&M University Health Science Center Department Ibt - Cedp - Dashwood Proposed Minimum Salary $5,084.00 monthly Job Location Houston, Texas Job Type Staff Job Description Our Commitment Texas A&M University is committed to enriching the learning and working environment by promoting a culture that respects all perspectives, talents & lived experiences. Embracing varying opinions and perspectives strengthens our core values which are: Respect, Excellence, Leadership, Loyalty, Integrity, and Selfless Service.

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