Senior Laboratory Research Scientist - Cader Lab

About the role

The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Cader lab utilises state-of-the-art techniques to study the metabolism of immune cells such as macrophages and dendritic cells. We seek to understand how metabolic dysfunction in these cells can predispose to conditions such as Inflammatory Bowel Disease (IBD) or Rheumatoid Arthritis. Guided by genetics, we look to uncover novel and disease-relevant molecular and cellular mechanisms of immunometabolic regulation. For example, we are currently investigating how specific metabolic pathways can affect redox-modification of the proteome, modulate tissue microenvironment sensing, and alter lipid-immune signalling in tissues of interest such as lymph nodes, liver and the gut. We are also interested in identifying the metabolites our cells are exposed to from the environment (such as those from our diet or microbiota). We want to learn how we sense and process these metabolites, and the forms of metabolic stress that can emerge if not handled correctly. In doing so, we wish to learn how our diet, microbiota, and other environmental factors can shape our immune system in health and disease. To address all these questions, we employ diverse and innovative tools and experimental techniques such as single-cell sequencing, 3D-imaging, mass spectrometry and genetic screens. https://www.crick.ac.uk/research/labs/zaeem-cader We are seeking an enthusiastic, hard-working and conscientious senior laboratory research scientist to join our new research team. This is an exciting opportunity to be part of our ambitious research programme to study novel disease-relevant biology and to help pioneer cutting-edge techniques in a world-leading institute. This position would be ideal for post-doctoral candidates with an interest and expertise in metabolism and/or immunology as well as animal experimentation. You will provide vital support across the group's varied research projects and shall contribute to these both intellectually and technically. You will work alongside the group leader and research team to design, develop and perform a broad range of advanced biological experiments. The candidate will also be expected to lead their own project. You will also help in training of students in core laboratory techniques. Whilst this is primarily a scientific role, the successful candidate will also be expected to work alongside the quadrant manager and wider Crick infrastructure to carry out the necessary management and safety activities needed for the smooth running of the group. You should already have extensive experience in mammalian cell culture, in vivo (mouse) experimentation and cell/molecular biology. You should also have familiarity and expertise across multiple immunology and/or metabolomic relevant techniques such as flow cytometry, microscopy, metabolomics or next-generation sequencing. Necessary support and training will be provided and we hope, for example, that the successful candidate will become a GC-MS super-user able to use this instrument independently. You will work supportively with other group members and actively contribute to the scientific dialogue within the lab. This is a great opportunity for a scientist looking for a varied and stimulating scientific role, to help support a new research group studying exciting and disease-relevant biology.

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Additional Information

Salary for this Role: From £47,080 with benefits, subject to skills and experience. Job Title: Senior Laboratory Research Scientist - Cader Lab Reports to: Zaeem Cader [C] Closing Date: 07/Jun/2026 23.59 GMT Job Description: Job Title: Senior Laboratory Research Scientist Details of the role: Reporting to: Dr Zaeem Cader, Clinician Scientist Group Leader Working pattern : This is a full-time, permanent position on Crick terms and conditions of employment. Salary: From £47,080 with benefits, subject to skills and experience. Application closing date: 7th of June 2026 at 23.59pm

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