Senior Researcher in Protein Technologies Center

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We are looking for a Senior Researcher to participate in our exciting studies of the human protein kinome. This Associate Scientist position is part of the Blue Sky Initiative " Seeing the Invisible in Protein Kinases " at St. Jude Children's Research Hospital in Memphis, TN. The Blue Sky Initiative "Seeing the Invisible in Protein Kinases" is an inter-disciplinary project in the Department of Structural Biology and is supported by US $50 million in institutional funding. This large-scale project leverages ultra-high field nuclear magnetic resonance (NMR), complemented with cryoEM, X-ray crystallography, data-science and computational approaches, to characterize the conformational landscape of the human kinome. Knowledge of kinase conformations is then used to discover new biology of kinase function and regulation in cells, understand the structural and functional consequences of disease-associated mutations, and identify novel therapeutic opportunities. As a member of the Protein Technology Centre /BlueSky team, the candidate will use their molecular biology, biochemistry, and biophysical skills to study the molecular mechanisms and structures of protein kinases and their cellular regulatory functions. Additionally, the candidate will assist in preparing high-quality proteins from various expression systems such as bacteria, insect cells and mammalian cells for structural studies of kinases using NMR, crystallography and cryo EM. The work is diverse, providing an opportunity to study multiple kinases, perform appropriate background research, optimize biochemical and biophysical assays and structural characterizations. Not only do the biophysical and structural studies characterize the molecular mechanisms of protein kinases, but they are also used to discover new mechanisms of kinase regulation and/or new kinase-mediated biology. St. Jude Children's Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine's and Glassdoor's "100 Best Places to Work" for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Minimum Experience: Two (2) years of research experience is required with a bachelor's degree. No prior experience is required with a Master's degree. Working knowledge and understanding of underlying concepts and principles of experimental design. Experience with the most widely used techniques used in the home laboratory. Proven performance in earlier role/comparable role.

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