Principal Cloud Engineer, Infrastructure - Onsite San Diego HQ

About the role

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X , Facebook and YouTube . ( *in collaboration with AbbVie ) The Principal Cloud and Infrastructure Engineer serves as the senior technical expert responsible for designing, modernizing, and optimizing enterprise-scale hybrid cloud environments across Azure, AWS, and on-premises infrastructure. This role leads cloud transformation initiatives including migration, automation, infrastructure modernization, FinOps optimization, and secure platform engineering while establishing architectural standards for scalability, reliability, compliance, and operational excellence. The position requires deep expertise in Azure cloud services, hybrid infrastructure, virtualization, networking, identity management, Infrastructure as Code (IaC), and container platforms, along with the ability to lead cross-functional initiatives and mentor engineering teams in highly regulated enterprise environments. _ Your Contributions (include, but are not limited to): Cloud Architecture & Infrastructure Modernization Lead enterprise-scale cloud transformation initiatives, including infrastructure consolidation, virtualization, hybrid cloud modernization, and migration strategies across Azure, AWS, and on-prem environments Architect scalable, resilient, and highly available cloud infrastructure solutions aligned with business, security, and compliance requirements Design and implement hybrid connectivity architectures leveraging Azure ExpressRoute, VPN, SD-WAN, private endpoints, and secure access technologies Develop disaster recovery, business continuity, and high-availability strategies across cloud and datacenter platforms Platform Engineering & Automation Champion automation-first engineering practices using Infrastructure as Code (IaC) technologies including Terraform, ARM/Bicep, and CloudFormation Design and implement API-driven, self-service infrastructure provisioning platforms integrated with ServiceNow, identity platforms, and CI/CD pipelines Standardize and automate infrastructure deployment, configuration management, patching, monitoring, and lifecycle operations Lead adoption of modern platform engineering practices supporting scalable and repeatable infrastructure delivery Cloud Operations, Optimization & FinOps Lead cloud governance, cost optimization, and FinOps initiatives across Azure and AWS environments, including consumption analysis, reserved instance strategies, rightsizing, and budgeting controls Establish operational standards for monitoring, observability, performance tuning, and incident response across hybrid infrastructure Optimize storage and compute utilization through lifecycle management, automated tiering, and workload balancing strategies Drive continuous improvement initiatives to enhance reliability, scalability, operational efficiency, and service performance Compute, Storage & Virtualization Architect and optimize VMware infrastructure platforms with a focus on footprint reduction, operational efficiency, resiliency, and automation Design scalable enterprise storage solutions across Azure, AWS (S3, FSx), and NetApp environments, including backup, replication, and lifecycle governance Enable secure, scalable compute platforms supporting containerized workloads, Kubernetes orchestration, analytics platforms, and modern application hosting requirements Security & Identity Integration Implement identity-driven access models using Active Directory, Azure AD/Entra ID, RBAC, and policy-based provisioning frameworks Integrate security best practices into all cloud and infrastructure architectures, including zero-trust principles, segmentation, encryption, and secure access controls Ensure compliance with enterprise security, audit, and regulatory standards across cloud and on-prem environments Collaborate with cybersecurity teams to implement governance policies, risk mitigation co

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