Scientist (Pooled Lentiviral Base Editing Screening)

Responsibilities

• Design, optimize, and execute pooled lentiviral screening workflows for large-scale base/prime editing mutagenesis.
• Collaborate closely with bioinformaticians and project investigators to ensure robust experimental design, data acquisition, and analysis.
• Drive the development of innovative experimental strategies to expand and enhance existing screening capabilities.
• Contribute to collaborative research outputs, including publications and conference presentations.
• Ideal Candidate:
• PhD (or equivalent experience) in Molecular Biology, Cell Biology, Genetics, or a closely related field.
• Demonstrated expertise in the design, production, and application of lentiviral vectors for genetic manipulation and screening.
• Proven track record in developing, implementing, or applying high-throughput genetic perturbation or functional screening approaches.
• Excellent organisational, communication, and record-keeping skills.
• Strong problem-solving ability and capacity to work independently as well as collaboratively.
• Desirable Attributes:
• Extensive experience in CRISPR-based genome engineering in mammalian cell systems.
• Demonstrated expertise in the design, production, and application of lentiviral libraries for large-scale screening.
• Experience with base or prime editing systems.
• Familiarity with large-scale data generation and interpretation in screening contexts.
• Evidence of contributions to collaborative research initiatives or consortia.
• About the Research Environment:
• Minimum Education and/or Training:
• Bachelor's degree in relevant scientific area is required.
• Minimum Experience:
• Eight (8) years of relevant work experience is required with a Bachelor's degree.
• Six (6) years of relevant work experience is r

Benefits

Additional Information

We are seeking a highly motivated and talented scientist to join our team and lead cutting-edge research exploring the therapeutic potential of intrinsically disordered regions. This project will harness pooled lentiviral screening platforms for base/prime editing mutagenesis to systematically perturb key molecular interactions. It offers an exciting opportunity to apply innovative high-throughput technologies to uncover new regulatory mechanisms and identify novel therapeutic targets. The successful candidate will play a central role in developing and implementing advanced lentiviral-based screening pipelines across diverse biological systems, working at the interface of molecular biology, genomics, and translational discovery. The World's Brightest Minds Always Innovate At St. Jude Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.

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