Senior Director, HEOR - Acoramidis (Global Lead)

Responsibilities

• Why This Role Matters
• Global HEOR Strategy: Define and lead the end-to-end global HEOR strategy for acoramidis across launch and lifecycle, ensuring alignment with clinical, regulatory, and commercial objectives and driving evidence-based decision-making
• Evidence Generation & Data Strategy: Design and oversee innovative real-world evidence (RWE), economic models, and data partnerships (e.g., claims, EHR, observational survey datasets) to support value demonstration and long-term evidence generation
• Payer & HTA Readiness: Develop robust, payer-relevant evidence packages and lead HEOR contributions to global HTA submissions, pricing, reimbursement, and access strategies
• Publications & Scientific Dissemination: Lead the HEOR publication strategy, including congress planning and peer-reviewed publications with Pubs teams, to establish a compelling and credible evidence narrative
• Patient-Centered Outcomes: Drive the development and integration of PROs and other patient-centered endpoints to demonstrate meaningful clinical benefit and differentiation
• Competitive Intelligence & Positioning: Proactively assess and anticipate competitive dynamics (including generics, pipeline entrants, and alternative therapies) to inform evidence strategy and positioning
• Cross-Functional Leadership: Partner closely with Market Access, Medical Affairs, Clinical, Regulatory, and Commercial teams to ensure cohesive and actionable evidence strategies
• Governance & Scientific Integrity: Ensure HEOR activities are conducted with scientific rigor and appropriate governance, maintaining independence of evidence generation while enabling compliant, impactful use
• External Engagement: Oversee external vendors, research partners, and academic collaborations to deliver high-quality, timely evidence outputs
• Where You'll Work
• This is a onsite role and requires in-office collaboration 2-3x per week in our San Francisco and Palo Alto Offices.

Requirements

• Advanced degree (PhD, PharmD, MPH, MD, or equivalent) in health economics, outcomes research, epidemiology, or related field
• 10+ years of progressive HEOR experience within biopharma or consulting, including leadership of global programs
• Demonstrated experience supporting product launches and payer strategy development in specialty or rare diseases preferred
• Strong understanding of global HTA frameworks (e.g., NICE, ICER, CADTH, G-BA) and payer evidence requirements
• Proven track record in RWE, economic modeling, and PRO strategy development
• Key Competencies
• Strategic, enterprise-level thinker with strong business acumen
• Ability to translate complex evidence into clear, compelling value narratives for diverse stakeholders
• Influential cross-

Benefits

Additional Information

Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a "moneyball for biotech" approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation-including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

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