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Scientist, LNP Process and Development

External
flagshippioneeringinc logoFlagshippioneeringinc · Cambridge, UK
Full-timeOn-site1mo ago
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About the role

We are seeking a highly motivated Scientist to support the development and scale-up of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on process optimization and scale-up of targeted LNPs encapsulating modified DNA and cofactor mRNA, while also contributing to research efforts aimed at improving LNP design and performance. This is an ideal opportunity for a scientist with a strong background in process development who is interested in expanding into formulation development and early-stage R&D, including formulation screening and optimization of next-generation LNP systems. The successful candidate will work collaboratively within cross-functional teams to advance LNP platform capabilities and support the development of scalable and robust nucleic acid delivery systems.

Responsibilities

  • Support process development and optimization activities for LNP formulation and scale-up, including mixing parameters, encapsulation efficiency, and reproducibility.
  • Design and execute experiments to improve the performance and manufacturability of LNPs encapsulating modified DNA and mRNA.
  • Collaborate with internal and external teams to support characterization and evaluation of LNP formulations.
  • Assist with technology transfer and scale-up activities, including coordination with external partners or internal manufacturing teams.
  • Analyze and interpret experimental data, maintain accurate documentation, and communicate findings to project teams.
  • Stay current with advancements in LNP technologies and nucleic acid delivery approaches.
  • Professional experience and qualifications
  • PhD. in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or a related field, with 3+ years of relevant industry experience; M.S. with 8+ years of experience; or Bachelor with 10+ years of experience.
  • Strong background in process development, scale-up, or manufacturing of nanoparticle or LNP-based systems.
  • Experience working with nucleic acid formulations (e.g., mRNA, DNA) is highly preferred.
  • Familiarity with T mixing, or similar, formulation scale-up, and characterization techniques (e.g., DLS, encapsulation assays).
  • Demonstrated ability to design experiments, analyze data, and solve complex technical problems.
  • Strong communication and collaboration skills.

Benefits

Opportunity to work at the forefront of LNP formulation innovationCollaborative, science-driven culture with high impact researchCompetitive compensation and benefits packageABOUT FLAGSHIP PIONEERINGAt Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its empHealth insurance

Additional Information

Company description Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

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