Scientist / Senior Scientist, Assay Development (Reagents)

Responsibilities

• Reagent Development & Formulation
• Lead assay reagent development activities, including formulation, characterization, and optimization, for components used in ProSE single-molecule expansion and library preparation workflows, including enzymes, oligos, beads, and solvents.
• Characterize reagent performance using design-of-experiments (DOE) approaches, systematically varying formulation conditions, buffer composition, excipients, and process parameters to establish operating bounds and define product specifications.
• Design and execute experiments to evaluate reagent performance in end-use assay configurations; develop a mechanistic understanding of how reagent composition, lot variability, and environmental sensitivity impact expansion assay outcomes.
• Design and execute reagent storage stability studies under accelerated and real-time conditions; develop stability-indicating assays; interpret results against established product specifications and flag out-of-spec trends proactively.
• QC Framework & Lot Qualification
• Build and implement a QC and control framework for platform reagents, including acceptance criteria, lot release protocols, and QC assay development, to support reliable, consistent supply to the Assay team.
• Qualify each reagent lot prior to use in multi-cycle or KOL runs; execute hands-on QC testing encompassing physical, chemical, and functional characterization; gate go/no-go decisions on input materials and maintain provenance records for high-stakes runs.
• Maintain batch records and quality documentation in accordance with internal standards.
• SOPs, Inventory & Continuous Improvement
• Establish and maintain SOPs for assay reagents and integrated workflows; systematically investigate lot-to-lot variability and failure modes; troubleshoot deviations and lead root cause analysis and corrective action.
• Guard-band critical reagent components and workflow steps to establish the operating bounds of new protocols and define tolerance limits for expansion assay parameters.
• Forecast and maintain end-to-end reagent inventory for SOP-level runs, ensuring the Assay team has qualified materials available on schedule for integration runs and platform demonstrations.
• Partner with the Automation team to implement and qualify reagent-dependent assay steps on work cell or Hamilton-based platforms; qualify liquid-handling methods against reagent specifications.
• Analyze experimental data using statistical methods; synthesize results to identify trends and trace them to upstream reagent, process, or formulation variables; communicate findings through te

Benefits

Additional Information

About Glyphic: At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you Glyphic is seeking a Scientist or Senior Scientist to build and sustain the reagent supply infrastructure that powers our single-molecule proteome sequencing platform. In this role you will own the full reagent lifecycle - from early formulation and characterization through stability qualification, QC method development, and lot release - ensuring that every critical material entering a multi-cycle expansion run meets Glyphic's performance standards. The ideal candidate brings deep hands-on expertise in biochemical reagent development with a quality-by-design mindset: methodical in experimental approach, rigorous in documentation, and proactive in building the frameworks that sustain consistency at scale. You have experience not just characterizing reagents but qualifying them - setting acceptance criteria, gating go/no-go decisions on incoming lots, and maintaining the provenance records that high-stakes single-molecule runs demand. You are comfortable working at the bench and translating your findings into SOPs, QC protocols, and reagent inventories that the broader Assay Development team can rely on. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

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