Research Fellow (Mechanobiology Institute)

Requirements

• PhD in Biophysics, Molecular Biology, Biomedical Engineering, or a closely related field .
• Strong background in membrane protein biochemistry, membrane biophysics, membrane modulation (ideally magnetic tweezer and micropipette manipulation), or single-molecule techniques .
• Experience with reconstitution of proteins into model membranes (e.g., liposomes, GUVs, supported bilayers) is highly desirable.
• Excellent problem-solving, communication, and organizational skills.
• Proven track record of peer-reviewed publications.

Additional Information

Interested applicants are invited to apply directly at the NUS Career Portal. Please note your application will only be processed if you apply via NUS Career Portal. NUS Career Portal link: https://careers.nus.edu.sg/job/Research-Fellow-%28Mechanobiology-Institute%29/32446-en_GB/?st=2BEE3E975B56E1CC0656038B6C6B070EF3DB1ED2 We regret that only shortlisted candidates will be notified. Job Description The Mechanobiology Institute (MBI) at the National University of Singapore (NUS) is a leading multi-disciplinary institute devoted to developing new paradigms for understanding biological functions in health and diseases from the perspective of cell, tissue and organ mechanics/dynamics and mechano-signal transduction. The institute operates on a fully integrated open-lab philosophy, with an extensive infrastructure supported by core facilities dedicated to technology such as state-of-the-art light microscopy, nano- and micro- fabrication, and computing. We are seeking a highly motivated and skilled Research Fellow to join our multidisciplinary team investigating the biophysical and mechanochemical properties of signalling proteins on 3D shaped membranes . The successful candidate will work at the interface of membrane biophysics, cell signalling, and nanofabrication-based membrane curvature control , contributing to a broader effort to understand how membrane environment regulates protein activation and signalling at the cellular and molecular levels. Responsibilities will include: Leading independent and collaborative research on curvature-regulated protein activation and signaling on membranes Developing and applying nanofabricated platforms (e.g., nanopillars, nanobars, nanorings) to probe membrane curvature effects Performing in vitro reconstitution (e.g., supported lipid bilayers, phase separation systems) and live-cell assays (e.g., T cell signaling) Utilizing advanced imaging techniques (e.g., confocal, TIRF, SIM, STED ) and quantitative image analysis Building and implementing computational pipelines for image quantification and biophysical analysis Contributing to high-impact publications, grant writing, and mentoring of junior researchers

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