Clinical Genomics Scientist, Oncology (Part-Time Contractor)

Responsibilities

• Somatic variant interpretation and data review : Perform somatic-based variant interpretation, diving into the literature and databases to classify variants and match treatments for reporting, performing verification as required with BAM file analysis.
• Clinical report drafting: Carefully draft reports for each requisition primarily using in-house reporting API, working closely with the engineering and QA teams on reporting, and the laboratory directors on report language.
• Content curation: Contribute to curation of gene-level content such as domain and critical residue curation.
• Contribute to oncology R&D : Work closely with the R&D team to help with somatic oncology based projects, providing expertise on variant interpretation, biological pathways/mechanisms, and other gene/variant-level reviews and analyses.

Requirements

• Ph.D. in Human Genetics, M.S. in Genetic Counseling, or related field
• 2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines in a clinical setting (alternatively, 1+ years of germline variant interpretation and 1+ years of somatic variant interpretation experience)
• Hands-on experience working with human mutation databases (COSMIC, ClinVar, OncoKB), functional annotation sources (dbSNP), and genome browsers (UCSC)
• Familiarity with IGV and BAM file analysis and data-minded willingness to learn to use basic bioinformatics tools, with technically minded insights
• Knowledge of cancer somatic mutation and signaling pathways (e.g., which mutations have FDA approved drugs, Phase II/III clinical trials, which mutations are considered "hot targets" for drug development, etc.)
• Exceptional attention to detail to follow highly detailed SOPs and strong organizational skills to track and manage clinical reporting and product improvement projects
• Excellent communication skills and ability to work collaboratively with cross-functional teams
• Ability to work on Saturday and/or Sunday, in addition to hours during the week.
• Benefits And Perks:
• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• For this position, the target hourly rate is: $100/hour.
• BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
• For more information about how we protect your information, we encourage you to review our Privacy Policy .
• BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-fr

Benefits

Additional Information

Ready to redefine what's possible in molecular diagnostics? Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today. Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong. We are looking for a Clinical Genomics Scientist, Oncology to join and support our Clinical Genomics team. You are responsible for helping with day-to-day commercial reporting operations, including variant interpretation and report drafting. Working closely with the clinical genomics team, you will help scale-up our ever growing reporting needs. This role is a part-time contracting position (10-20 hrs/week) and will report to the Senior Manager, Clinical Genomics, Oncology in a remote-based position. We are looking for someone with long-term engagement interests and able to commit to a minimum of 1 year or longer. If you have a strong commitment to improving patient care through clear clinical reporting, have experience in somatic variant interpretation and report drafting, enjoy digging into the technical side of the data alongside bioinformatics, and thrive in a fast-paced entrepreneurial environment, this could be a perfect opportunity for you.

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