Assay Integration Lead

Responsibilities

• Team Leadership & Strategy
• Lead, develop, and grow a team of scientists responsible for assay integration and end-to-end workflow development; establish clear goals, foster professional growth, and build a culture of scientific rigor, accountability, and continuous improvement.
• Define team priorities, milestones, and resource needs in alignment with Glyphic's platform development roadmap; allocate team capacity and arbitrate trade-offs between competing experiments, integration runs, and instrument time.
• Serve as the organizational owner for assay integration, setting the standard for high-quality, platform-ready execution and ensuring the team delivers against it consistently; communicate progress, risks, and trade-offs proactively to senior leadership and cross-functional partners.
• Collaborate with assay research, chemistry, automation, and data science teams to deliver integrated, scalable solutions to complex technical challenges; represent the Assay Integration team as a peer leader in cross-functional forums.
• Develop and maintain end-to-end assay controls that enable QC, performance benchmarking, quantification of improvements from new reagents and workflow steps, and systematic identification of gaps.
• Own the full lifecycle of SOP development, maintenance, and versioning for the integration function.
• Technical Oversight & Hands-on Contribution
• Reagent Development & Control Strategy
• Oversee fit-for-purpose reagent development, ensuring all critical assay components are sufficiently robust to tolerate variability in assay conditions and environment without premature over-optimization.
• Define critical reagent parameters and establish guard-band operating zones that ensure performance reliability across the expected range of assay and environmental variability.
• Develop QC methods and acceptance specifications for assay reagents (including oligos, expanders, beads, solvents, and enzymes) and assess performance of instruments, substrates, and reagent systems.
• Build and maintain a control strategy with defined positive controls for assay performance and acceptance criteria for reagent lots.
• Establish SOPs for reagent preparation; systematically investigate lot-to-lot variability and failure modes; forecast and maintain reagent inventory to support integration-scale runs.
• Manage a team of scientists evaluating and qualifying assay components for integration into sample preparation, molecular expansion, and library preparation workflows.
• Work Cell & End-to-End Workflow Integration
• Own the assay integration process across the work cell and end-to-end workflow, ensuring all steps are accounted for and gaps are proactively identified and resolved.
• Define assay requirements for the work cell, including deck layout, reagent and consumable needs, and operating parameters, and be sufficiently hands-on to translate those requirements into physically and operationally sound configurations.
• Integrate upstream sample preparation workflows into the expansion assay; validate end-to-end compatibility, yield, and contaminant carryover; ensure a consistent and timely supply of samples for ongoing assay evaluation.
• Oversee the integrati

Benefits

Additional Information

About Glyphic: At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you Glyphic is seeking an experienced scientist and team leader to serve as Senior Manager / Associate Director of Assay Integration. In this role, you will build and lead a team of scientists working at the intersection of assay development, reagent and control strategy, and automation. Together, you will translate experimental workflows from early-stage concepts into the robust, reproducible, and scalable processes that power our single-molecule proteome sequencing platform. Reporting to the Director of Assay Development, you will bring both deep hands-on technical expertise and the leadership presence to set clear direction, develop talent, and deliver results across complex cross-functional programs. You will own the end-to-end assay integration process across the work cell, from defining reagent requirements and QC specifications to designing workflows, enabling throughput, and qualifying processes as the platform evolves. The ideal candidate has a demonstrated track record of taking assay workflows from prototype to platform-ready reality, and the management experience to build a team that does the same, systematically, at high quality, and with urgency. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

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