Sr Scientist II, Multispecific Antibody Engineering, Oncology

Responsibilities

• Design, engineering, and production of multispecific biologics to support AbbVie's Oncology therapeutic area; apply design and engineering experience with multispecific biologics for ADC and immuno-oncology applications.
• Manage a group of scientists within the multispecific team, focusing on the design, production, characterization of multispecific biologics, and management of multispecific inventory.
• Serve as the biologics lead on multispecific biologics projects, coordinating activities and transitions from hit generation through candidate nomination.
• Serve as a multispecific engineering representative on cross-functional teams; recognized as an expert in multispecific design and production.
• Identify and solve technical problems independently, conceive, and implement innovative processes in research ideas.
• Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed scientific papers or patents.
• PhD or MS degree in Biochemistry, Biochemical engineering or related disciplines + (PhD) or 12+ (MS) years of experience in multispecific engineering or antibody engineering
• Experience with protein, biologics, fragments, or multispecifics (e.g. bispecifics, trispecifics, bispecific protein fusions) design, expression and purification
• In-depth knowledge of the multispecific landscape, trends in design, and application across therapeutic areas including immunology, oncology, and neuroscience
• Ability to recognize emerging areas of interest in multispecific engineering, antibody engineering, and related fields, and make connections between research ideas to advance platforms and programs
• Excellent organizational skills and the ability to manage multiple projects simultaneously
• Team player with the ability to operate in a fast-paced multi-disciplinary environment
• Candidate must be a goal-oriented team player with excellent verbal and written communication skills and strong can-do attitude

Requirements

• Experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
• Experience with mass spectrometry analysis and software (Protein Metrics)
• Experience with CRO coordination for production
• Expert understanding of current state of protein expression/separation/analytical technologies
• Extensive knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
• Experience managing direct reports and providing performance evaluations and development opportunities
• Recognized in the scientific community through a sustained record of peer-reviewed publications and patents preferred
• Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our long-term incentive programs.
• AbbVie is an equal opportunity employer and is committed to operating with integrit

Benefits

Additional Information

Discovery Biotherapeutics at AbbVie is seeking a highly skilled, self-motivated scientist to join a dynamic team supporting the design, engineering, and manufacturing of multispecifics. This position will have a significant impact by managing a group of scientists focused on design, production, and characterization of multispecific biopharmaceutical products. The ideal candidate will have extensive experience with biologics and multispecific production platforms, analytical characterization, and a proven track record of implementing multispecific engineering and production strategies to advance early- and late-stage discovery programs in ADCs and immuno-oncology. The ideal candidate should also have experience managing a small multispecific engineering team in a discovery setting. The successful applicant will be an enthusiastic, creative scientist who makes tangible contributions to continuous improvement and innovation within the organization.

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