Scientist II - Biology

Requirements

• Prior experience with in vitro assay development, execution, and optimization for drug screening, ideally within a drug discovery setting
• Experience in designing and delivering biology strategies for research projects
• Excellent and proven project management skills
• Complete understanding and wide application of technical principles, theories, concepts and techniques
• Knowledge of and ability to use standard molecular and cell biology techniques are required, for example, Western blotting, microscopy, plate-based assays and qRT-PCR
• Asceptic mammalian cell culture experienced is required
• Knowledge of breast cancer and/or cancer signaling pathways preferred
• Knowledge of scientific principles and concepts, and current on relevant scientific literature
• Good general knowledge of other related disciplines
• Ability to read, analyze and interpret common scientific and technical journals
• Strong publication track record in oncology, biochemistry and/or drug discovery
• Experience working with high t

Benefits

Additional Information

Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential. Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you're ready to join us at the edge of something unstoppable, let's make a profound impact together for our patients, for your career, for what's beyond . You can view our latest corporate deck and other presentations here . About the role >>> Scientist II - Biology Olema Oncology is currently seeking a talented and innovative Scientist II to join the Research Biology team as a screening specialist. Responsibilities of this position will include developing biology specific strategies for early-stage research projects, development and execution of biochemical and/or cellular phenotypic screening assays of new drug candidates as well as management and mentorship of junior scientists within the team. You will be responsible for conducting experiments to generate high quality data and communicate these results regularly within our project teams. You will work collaboratively within the research team to assist in the conduct of early-stage research, the goal of which is the identification of New Chemical Entities (NCEs). The Scientist II in our Research Biology organization will support adherence to all regulatory requirements and company Standard Operating Procedures (SOPs). The final level may be adjusted based on the experience of the candidate. This role is based out of our San Francisco office and requires approximately 10% travel. The selected candidate will be responsible for: Design, optimization and execution of primary screening experiments, the goal of which is the identification of additional hits and new chemical scaffolds Provide support for lead optimization by screening compounds and/or supporting structure activity relationship (SAR) studies involving the characterization of the biological activity of compounds in various assays Presentation and communication of results as part of multi-disciplinary team(s) Manage and program automated systems (liquid handlers etc) for medium/high throughput screening assays Assist in the identification/validation of new targets for drug discovery programs Mentor junior team members Work cross-functionally within the Research team, design and communicate Biology strategy and workflows to progress projects from hit to lead onwards Apply relevant scientific principles and techniques to research problems Maintain detailed electronic laboratory notebooks (ELN) and record results in a timely manner Maintain knowledge of state-of-the-art principles and techniques Present findings internally and externally and contribute to the publication of the work of the project team May contribute to the development of patent applications as appropriate Comply with all safety requirements General lab duties as assigned Ideal Candidate Profile >>> A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role. Knowledge PhD. in Cancer Biology, Pharmacology, Biochemistry, or a related field 3+ years of relevant industry experience, preferably in small molecule drug discovery

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