Senior Principal Scientist, Process Chemistry

About the role

Pfizer's purpose is to deliver breakthroughs that change patients' lives. At the core of fulfilling this purpose is Research and Development, where we translate advanced science and technologies into impactful therapies and vaccines. Your work will encompass all facets of development, from small-scale synthesis supporting Discovery programs to developing the commercial synthetic route. Through your expertise and extensive knowledge, you will foster a culture that promotes innovation and thrives on improving outcomes for patients and healthcare. ROLE SUMMARY: Lead technical teams to design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale‑up. Develop fit‑for‑purpose processes for early‑ and late‑stage programs, ensuring safety, robustness, and scalability. Lead authorship of patents, publications, and regulatory documents. Apply modern synthetic organic chemistry principles, high‑throughput experimentation, mechanistic insight, and data‑rich methods to accelerate development. Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions. Drive alignment to project timelines and portfolio strategy. Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment. Lead technology transfer and partner interactions to enable external development campaigns. Build strong stakeholder relationships across process chemistry, partner functions, and project teams. Maintain an external technical presence through publications and presentations.

Requirements

• PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development, including route design, scale‑up, and GMP manufacturing
• Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies.
• Demonstrated scientific impact via peer‑reviewed publications, patents, or conference presentations.
• Strong communication skills with demonstrated collaborative leadership in cross functional process development teams.
• Experience supporting development from preclinical through commercial stages.
• Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.
• Proficient in current Good Manufacturing Practices (GMP)
• Skilled in reaction modeling, material property prediction, and simulation using advanced computational tools such as DynoChem, gPROMS, Visimix, Aspen, Fluent, and Cosmotherm
• Experience in regulatory filing and compliance
• Experience developing drug‑linkers for ADCs, PROTACS, DACs or other targeted mixed‑modality therapeutics.
• Experience mentoring and developing scientific staff.
• Experience with technology transfer and oversight of external development work.
• Experience at innovator pharmaceutical companies is strongly preferred.
• Additional Job Details:
• Work Location Assignment: On Premise
• Last date to apply is June 25, 2026
• Relocation assistance may be available based on business needs and/or eligibility.
• Candidates must be authorized to be employed in the U.S. by any employer.
• U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
• Sunshine Act

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