Director, Translational Science Lead

Responsibilities

• Disease Biomarker Strategy Development and Delivery:
• Translational Leadership:
• Translational innovation:
• o Evaluate novel techniques and technologies (i.e. spatial transcriptomics) to inform translational initiatives, biomarker development and validation working in collaboration with platform teams and within a multi-functional matrix environment.
• o Identify and guide validation of human assays (cells, tissues and organs) to enhance human translation and predictive value through the application of resources such as the Human Cell Atlas, disease tissue multi-omics data and genetic resources (external or proprietary).
• Cross-functional Collaboration:
• External Partnerships:
• o Establish and maintain strategic collaborations with academic institutions, contract research organizations (CROs), and other external partners to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
• o Foster a network of external experts and key opinion leaders to stay at the forefront of translational science and biomarker advancements across the industry.
• o Contribute to evaluation and diligence of business development opportunities.
• Matrix Leadership:
• o Provide mentorship, guidance, and professional development opportunities to ensure a high-performing and motivated team.
• o Manage disease and project level resources, budgets, and timelines to ensure the successful execution of projects and achievement of milestones and TS objectives.
• o Represent TS at portfolio governance reviews providing critical input to pipeline and investment decision making.
• Why you?

Requirements

• We are looking for professionals with these required skills to achieve our goals:
• Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field)
• Associate Director or Director-level experience in translational science and biomarker development within the pharmaceutical or biotechnology industry.
• Recognised translational/biomarker expert in scientific community through publications and contributions to the field.
• Higher education or experience in translation and biomarkers implementation in Renal, Inflammation and / or Fibrotic indications.
• Experience of working in a clinical trial setting, working as part of a clinical study and experience of authoring and oversight of clinical and regulatory documents
• Working knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation.
• Broad knowledge and experience in technologies and methods used in translational research.
• Proven track record of program decision making through implementing biomarker strategies and delivering translational science insights in support of drug progression through clinical transition milestones.

Additional Information

443218 Director, Translational Science Lead Renal, Inflammation and Fibrosis and Neurodegeneration Translational Sciences (TS), within Respiratory, Immunology and Inflammation Research Unit (RIIRU) therapy area is accountable for end-to-end disease area translational science to inform therapy area and program level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher confidence asset related decisions. This includes generation of foundational data as well as disease biomarker development and validation that allow timely deployment of tools/biomarkers to support Proof of Mechanism (PoM), signs of clinical efficacy, Proof of Concept (PoC), and pairing Mechanisms of Action (MoAs) with patient subtypes to predict responder populations.

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