Principal Scientist, Cancer Biology
External
Generalproximity · San Francisco, CAPrepare for this interview
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About the role
Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won't drag you
Requirements
- Experience navigating IND-enabling studies and working on teams that have successfully advanced research to the clinic
- Experience working at the interface of cancer biology and chemistry
- Familiarity or experience with PROTAC/next-gen IPM technologies
- Experience with PPI techniques (e.g., BRET, APEX/BioID, AlphaScreen etc.)
Benefits
Additional Information
tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate cancer biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced cancer biologist to help lead our Biology Team. In this position, you will help lead and manage our Biology Team and work closely with our Platform Team in the development of our core drug discovery technology. Your responsibilities will include phenotypic assay development, establishing pre-clinical in vitro/in vivo studies, performing mechanistic studies on lead drug molecules, spearheading forays into new oncology indications, and grant writing. About You High Agency. Initiative, independence, and self-accountability are some of our most valued traits. Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team. Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way. Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too. Qualifications & Nice-To-Haves PhD in Cancer Biology, Cell Biology, or related field. 5-7+ years of industry experience. Deep understanding of small-molecule drug discovery and its relationship to human disease. Exceptional leadership, interpersonal, and communication skills, with a track record of managing high-performing, multidisciplinary teams. Strong experience with : Cellular and molecular biology, including cancer cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning etc. Pre-clinical characterization and mechanistic elucidation of small-molecule drug candidates Mechanistic studies of cancer cell signaling and PTM analysis Phenotypic assay development for cancer drug discovery (low to high throughput) Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies) Proficiency in: Managing a team of exceptional scientists and research associates Target/indication selection Animal models of cancer (GEMM, orthotopic, xenograft models), in vivo study design, and PK/PD interpretation Managing CROs for in vitro and in vivo studies Grant writing
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