Portfolio / Program Manager - Operational Readiness (New Facility Introduction)

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Business Introduction We manufacture and supply reliable, high-quality medicines and vaccines to meet patients' needs and drive our performance. Our network of 37 medicines and vaccines manufacturing sites delivered 1.7 billion packs of medicines and 409 million vaccine doses in 2024 to help make a positive impact on the health of millions of people. Our supply chain is not just core to our operations; it's vital to bringing our innovations to patients as quickly, efficiently and effectively as possible. Technology is transforming how we manufacture medicines and vaccines, enabling us to increase the speed, quality and scale of product supply. We need the very best minds and capability to help us on our journey to make more complex products, harnessing the power of smart manufacturing technologies including robotics, digital solutions and artificial intelligence to deliver for patients. Position Summary GSK is embarking on the development of a state-of-the-art manufacturing facility, representing an $800M+ investment in advancing pharmaceutical innovation. This project offers an exciting opportunity to be part of a transformative initiative that will shape the future of manufacturing and operational excellence. The Portfolio & Program Manager - Operational Readiness is accountable for end-to-end operational readiness planning and execution for a new facility introduction. The role integrates cross-functional workstreams into a single executable readiness plan, drives schedule acceleration opportunities, ensures governance discipline, and enables "operational excellence from day one" through GPS and digital foundations. The role operates in parallel with construction/commissioning activities to ensure the site is ready to accept handover and achieve successful PPQ / facility approval readiness through robust SOPs, training, tech transfer alignment, incoming materials readiness, procurement execution, and risk controls. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: 1. Integrated Operational Readiness Plan & Schedule Build, maintain, and govern the integrated operational readiness schedule across workstreams (SOPs, Tech Transfer, GPS, Incoming Materials, Procurement) aligned to the Integrated Master Schedule and critical path. Drive schedule convergence and acceleration: identify dependencies, sequencing conflicts, resourcing gaps, and pull-forward actions; run weekly lookahead planning and escalation for overdue/at-risk deliverables. Establish readiness stage-gates and define entry/exit criteria with stakeholders to confirm readiness at critical milestones. 2. Cross-Functional Workstream Coordination SOPs & Document Readiness Coordinate prioritization, drafting, field shakedown, review, and approval of SOPs to enable shopfloor readiness. Ensure clear document strategy and ownership (e.g., what lives in SOP vs eBR vs local instructions) and maintain a document tracker integrated into the master schedule. Oversee the tracking and management of closure for safety, HAZOP, and risk assessment open items, ensuring all actions are completed in a timely manner. Coordinate effectively across teams to guarantee proper resolution and communication of outstanding safety and risk-related tasks. Tech Transfer / Readiness Interface Ensure operational readiness deliverables and timing remain aligned to Tech Transfer plans, donor site inputs, and QC method transfer planning. Integrate key Tech Transfer and QC readiness milestones into site reporting and governance. Oversee change control processes to ensure they are fully aligned with regulatory requirements, optimized for efficiency, and consistently executed according to established schedules. Continuously evaluate and refine change management practices, promoting accountability and timely decision-making to support project objectives and operational excellence. GPS and Lean Six Sigma / Operating System Deployment Drive operational excellence foundations: tier governance cadence, GEMBA/self-inspection routines, and readiness operating model embedded from the start. Enable stable execution through standard work, performance management, and continuous improvement rituals. Incoming Materials & Supply Readiness Coordinate supplier transparency setup, material master data readiness, BOM redlines, and incoming materials strategy/list development. Ensure materials readiness is linked to eBR/MES needs, procurement lead times, and commissioning/start-up sequencing. Procurement & Package Readiness Track procurement readiness for key packages and readiness blockers; coordinate mitigations where procurement timing threatens critical path. Partner with Engineering/Project teams to ensure procurement deliverables support FAT/SAT, start-up, and operational readiness needs. Smart Manufacturing Deployment Ensure the integration of smart manufacturing technologies and digit

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