Postdoctoral Fellow - Hyun Jung Kim Lab

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At Cleveland Clinic Health System, we believe in a better future for healthcare. And each of us is responsible for honoring our commitment to excellence, pushing the boundaries and transforming the patient experience, every day. We all have the power to help, heal and change lives - beginning with our own. That's the power of the Cleveland Clinic Health System team, and The Power of Every One. Job Title Postdoctoral Fellow - Hyun Jung Kim Lab Location Cleveland Facility Cleveland Clinic Main Campus Department Job Code X1004 Shift Variable Schedule 12:00am-12:00am Job Summary Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. Compensation follows the NIH NRSA Postdoctoral Salary Scale based on total years of postdoctoral experience. Job Details NIH NRSA Postdoctoral Salary Scale Years of Experience: Stipend for FY 2026 0: $63,480 1: $63,900 2: $64,380 3: $66,948 4: $69,180 5: $71,748 6: $74,424 7 or More: $77,076 POSITION 1: Microbiome-Associated Anti-Cancer Therapeutics in Organ-on-a-Chip Platforms We seek postdoctoral researchers to investigate how gut microbes modulate immune checkpoints on colorectal cancer (CRC) cells. Using patient-derived CRC organoid models, we have demonstrated that live gut bacteria reduce the expression of surface immune checkpoints through an enzymatic mechanism. Successful candidates will identify the responsible microbial enzymes and elucidate their mechanism of action. Strong candidates will have expertise in one or more of the following: microbial biochemistry and enzymology; glycobiology and carbohydrate-active enzymes (CAZymes); proteomics-based target identification; protein engineering; or microbial synthetic biology. Experiences in engineering designer probiotics or liver biotherapeutics for targeted payload delivery or tumor-localized sensing are highly desirable. Candidates trained in host-microbiome biochemical interactions, glycoprotein processing, microbial physiology, or AI-assisted synthetic biology are especially encouraged to apply. POSITION 2: Microbiome-Associated Disease Modeling in Organ-on-a-Chip Platforms We seek postdoctoral researchers to investigate how the gut microbiome drives human GI diseases using next-generation organoid and organ-on-a-chip platforms. Working at the interface of microbiology, disease biology, and bioengineering, successful candidates will join transdisciplinary collaborations with physician-scientists, immuno-oncologists, and pharmaceutical partners to elucidate microbiome-driven mechanisms underlying inflammatory bowel disease (Crohn's disease and ulcerative colitis), intestinal fibrosis, CRC, celiac disease, and GI infectious diseases, advancing precision therapeutics and translational medicine. Ideal candidates will have expertise in one or more of the following: organoid and 3D cell culture; host-microbiome crosstalk and mucosal immunology; cellular and molecular phenotyping; mechanobiology and biophysical processes; or GI disease pathology. Candidates with hands-on experience in organ-on-a-chip, microphysiological systems (MPS), or new approach methodologies (NAM) are especially encouraged to apply. A strong foundation in traditional biochemistry or cell biology, combined with enthusiasm for emerging microphysiological platforms, is equally welcome. This position offers a unique opportunity to contribute to high-impact translational research at the convergence of microbiome science, disease modeling, and next-generation in vitro technologies. Principal Investigator: Hyun Jung Kim, PhD Cleveland Clinic Research Department: Inflammation and Immunity Lab Research Topics: Microbiome-Associated Anti-Cancer Therapeutics in Organ-on-a-Chip Platforms Microbiome-Associated Disease Modeling in Organ-on-a-Chip Platforms For more information about the lab's research, please contact kimh19@ccf.org Education: PhD or MD/PhD required MD with relevant laboratory experience may substitute for PhD Languages: English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status Work Experience: Previous experience in a research or academic setting. Graduate student experience meets this requirement. Scientific writing experience Physical Requirements: Ability to perform work in a stationary position for extended periods Ability to operate a computer and other office equipment Ability to communicate and exchange accurate information Ability to distinguish color Manual dexterity to handle specimens and repair equipment

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