Senior Postdoctoral Research Scientist in Mass Spectrometry-based Immunopeptidomics

About the role

Location: Oxford Centre for Immuno-Oncology, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ We are seeking to appoint a Senior Postdoctoral Research Scientist in Immunopeptidomics with a strong interest in cancer immunology and innovative approaches for antigen discovery in cancer vaccine development. This research programme is focused on deciphering the molecular architecture of the HLA antigen processing and editing machinery, and investigating how it shapes tumour-specific antigen presentation. Your project will be to focus on identifying tumour-specific and immunogenic antigens from primary tumour tissues using advanced immunopeptidomic approaches. You will have hands-on experience with mass spectrometry-based proteomics, including instrument operation, maintenance, and data analysis workflows. You will join the T-cell Antigen Discovery Group, led by Dr Eleni Adamopoulou, within the Centre for Immuno-Oncology, directed by Professor Tim Elliott. You will be responsible for performing sample preparations, LC-MS/MS data acquisition, and in-depth data analysis to support the discovery and validation of tumour-specific antigens. You will maintain mass spectrometry instrumentation to ensure reliable performance and data quality. You will develop and implement novel highly-sensitive immunopeptidomic workflows for data acquisition by LC-MS/MS pipelines to advance neoantigen discovery. It is essential that you hold a PhD/DPhil in Chemistry, Biochemistry, Immunology, Molecular Biology, or a related field. Strong knowledge of biochemistry and molecular biology relevant to proteomics and immunopeptidomics is a must. It is also essential to have hands-on experience in operating and and maintaining Bruker and/or Thermo LC-MS/MS platforms. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. This position is offered full time on a fixed term contract until 31 December 2027 and is funded by CIO. Only applications received before 12 midday on Monday, 20 July 2026 will be considered. Please quote 187178 on all correspondence. £49,119 to £58,265 with a discretionary range to £65,336 p.a. (pro rata).Research Grade 8. This is inclusive of a pensionable Oxford University Weighting of £1,730 per year (pro rata).

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