Senior Research Associate, Fermentation Development

About the role

We are seeking a highly motivated Senior Research Associate to support the development and optimization of microbial fermentation processes for recombinant protein production. Reporting to the Principal Scientist, Bioprocess Development, this individual will play a key role in executing and scaling aerobic microbial fermentation workflows in a fast-paced startup environment. The ideal candidate is highly hands-on, technically rigorous, and comfortable operating independently in a dynamic research setting. This role requires strong practical experience with bench-scale bioreactors, microbial culture techniques, fermentation analytics, and laboratory operations.

Responsibilities

• Fermentation Operations
• Operate, monitor, and troubleshoot bench-scale aerobic microbial fermentation systems with minimal supervision
• Execute batch and fed-batch fermentation experiments to support process development objectives
• Prepare media, inoculum, feeds, and process solutions for fermentation campaigns
• Perform reactor setup, sterilization, calibration, and post-run cleaning/maintenance
• Sampling & Analytical Support
• Collect and process fermentation samples throughout cultivation runs
• Perform routine analytical assays including OD measurements, metabolite analysis, and sample preparation for HPLC or related analytical platforms
• Track fermentation performance metrics including biomass, substrate consumption, and product formation
• Strain Evaluation & Process Development
• Support screening and characterization of microbial strains in shake flask and bench scale bioreactors
• Assist in process optimization studies, including media development and fermentation parameter evaluation
• Maintain accurate and well-organized experimental records and documentation
• Laboratory Operations
• Generate and maintain microbial cell banks and inventory records
• Coordinate ordering and tracking of fermentation consumables and raw materials
• Support routine laboratory maintenance, equipment upkeep, and troubleshooting
• Contribute to safe laboratory operations and maintain a strong culture of safety and operational rigor
• Cross-Functional Collaboration
• Collaborate with strain engineering, downstream, and analytical teams to support integrated process development activities
• Assist with scaling workflows and implementing improved operational practices as the platform grows
• PROFESSIONAL EXPERIENCE & QUALIFICATIONS
• Bachelor's degree (with 5-7 years of relevant research experience) or Master's degree (with 3-5 years of relevant research experience) in Bioengineering, Chemical Engineering, Microbiology, Biotechnology, or related discipline.
• Hands-on experience in microbial fermentation, microbiology, bioprocess development, or related laboratory environments
• Experience in operating and maintaining bench-scale bioreactors
• Strong understanding of aseptic technique and microbial culture handling
• Experience with aerobic microbial fermentation workflows
• Strong organizational and documentation skills
• Ability to independently execute experiments and troubleshoot routine process issues
• Preferred Experience
• Experience with fed-batch fermentation processes
• Familiarity with HPLC-based analysis of sugars, organic acids, or fermentation metabolites
• Experience with recombinant protein expression systems
• Experience supporting process optimization or scale-up activities
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Benefits

Additional Information

COMPANY DESCRIPTION Flagship Pioneering is a platform innovation company that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health, sustainability and beyond exponentially accelerate scientific progress in areas ranging from disease detection and treatment and nature-positive agriculture to novel applications of AI that are driving the creation of new technologies. What sets Flagship apart is our ability to advance science and technology by uniting innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies.

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