Associate Scientist Antibody Discovery

Responsibilities

• Work closely with mAb discovery platforms to support molecular biology workflows; design and execute construct generation for antibody expression.
• Perform DNA preparations to generate high-quality plasmid material for mammalian cell transfection.
• Develop and optimize high-throughput mammalian cell-based production platforms for recombinant antibodies, antigens, and other biologics.
• Establish scalable transient and stable expression workflows in CHO, HEK293, and other mammalian expression systems.
• Purification using AKTA chromatography systems.
• High-Performance Liquid Chromatography Size Exclusion Chromatography (HPLC-SEC) analysis of purified proteins.
• Molecular assessment of early-stage development candidates (polyreactivity ELISA, CE-SDS, SEC-MALS, DSF)
• Maintain accurate and timely ELN data
• Preferred skills:
• Experience with modern AKTA chromatography systems (FPLC) for affinity capture and SEC chromatography
• Experience with high-throughput automated protein purification systems (e.g. Kingfisher)
• Experience with antibody-related bioinformatic/software packages.
• Expertise in high-throughput molecular biology approaches for construct generation
• Experience with mAb characterization techniques (FACS, BLI, epitope binning).
• Minimum Education and/or Training:
• Bachelor's degree in a relevant scientific area
• Minimum Experience:
• 7 + years of research experience is required
• 5 + years of research experience is required with a Master's degree
• 2 + years of research experience is required with a PHD
• Experience leading and supporting research experiments preferred
• Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
• Experience in guiding and training other laboratory personnel preferred
• Proven performance in earlier role/comparable role

Benefits

Additional Information

Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children's Research Hospital, that no child will die at the dawn of life. Antibody Discovery Collaborative Centre (ADCC) within the Department of Host Microbe Interactions at St. Jude seeks a skilled and highly motivated protein sciences candidate with experience in gene-to-protein workflows. This role will be responsible for developing and implementing strategies that improve the efficiency, scalability, and fidelity of molecular biology processes, ensuring that downstream teams receive high-quality protein and biologics for discovery purposes. Candidates with experience in protein engineering, expression and validation of biologics are encouraged to apply.

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