Define and lead the framework, standards, and operating model for integrated evidence generation, including processes and cross-functional ways of working, to enable consistent, high-quality development and execution of Integrated Evidence Plans (IEPs) across programs
Partner with Global Medical Leads and cross-functional teams to support development of IEPs and align on medical evidence generation approaches
Translate IEP priorities into execution-ready evidence generation plans, including study concepts, protocols, data sourcing strategies, analytical approaches, and input into Disease Monitoring Programs (DMPs)
Serve as an internal subject matter expert on real-world data (RWD) and real-world evidence (RWE), providing strategic guidance on data source selection, methodological approaches, and application of RWD/RWE to inform evidence generation and decision-making
Establish and advance structured data planning approaches and enable selection of fit-for-purpose data sources (e.g., EMR, claims, registries, PROs, and DMP-derived data), ensuring consistency, quality, and utility of data across programs
Requirements
Advanced degree (PhD, PharmD, or equivalent)
12+ years of experience in Medical Affairs, Clinical Development, Epidemiology, HEOR, or Evidence Generation
Proven experience designing and executing real-world evidence, observational studies, registries, or non-interventional research
Deep expertise in integrated evidence planning and evidence generation strategy
Strong background in rare diseases or small population research preferred
Demonstrated leadership of cross-functional global teams
Benefits
Vision insuranceRemote work options
Additional Information
Why Join Us?
Be a hero for our rare disease patients
At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won't go - challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them.
Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth - so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work.
If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team .
Position Summary:
ultra focused - Work together to fearlessly uncover new possibilities
Ultragenyx is seeking a highly experienced and strategic Senior Director, Evidence Generation to lead global post ‑ approval and late ‑ stage evidence strategy across the company's rare disease portfolio. Working in close partnership with Global Medical Leads, this leader will define and execute integrated evidence plans that support patient access, inform clinical practice, and strengthen the scientific understanding of real ‑ world disease and treatment outcomes.
The successful candidate will bring deep expertise in rare/ultra-rare disease research, strong experience in real-world evidence and non-interventional methodologies, and a proven ability to lead complex, cross-functional evidence generation programs.
Work Model:
Remote: Officially documented as working full-time from home, with travel to Ultragenyx's offices or other locations on occasion as needed.
Ultragenyxpharmaceutical · Remote