Bioanalysis: plasma and tissue processing/analysis to determine the drug concentration using the Sciex LC/MS-MS.
Plasma Protein Binding Studies: Conduct experiments to determine the binding affinity of compounds to plasma proteins using Sciex LC/MS-MS
Microsomal Assays: Perform microsomal stability studies to assess the metabolic stability and run the assay using the Sciex LC/MS-MS
Data Analysis and Interpretation: Analyze experimental data using appropriate software (WNL) and statistical methods and provide clear and concise summaries of findings to support decision-making.
Documentation and Reporting: Maintain detailed records of experimental procedures, results, and observations in laboratory notebooks and electronic databases. Prepare technical reports and presentations for internal meetings and regulatory submissions.
Collaboration: Collaborate effectively with cross-functional teams, including medicinal
chemistry, pharmacology, and toxicology, to support drug discovery and development projects.
Lab Maintenance: Ensure proper maintenance and organization of laboratory equipment, reagents, and supplies. Adhere to safety protocols and maintain a clean and safe working environment.
Requirements
Bachelor's with 3 to 5 years of experience or Master's degree in Pharmaceutical Sciences, Chemistry, Biochemistry, or a related field with 2 to 4 years.
Hands-on experience with DMPK assays, including screening, plasma protein binding, and microsomal assays are preferred but not required.
Proven analytical and problem-solving skills, with the ability to critically evaluate and interpret experimental data.
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Pay Range:
In the U.S., the hiring pay range for fully qualified candidates is $54.30-$63.35 per hour. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
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Cytokinetics is an Equal Opportunity Employer
Benefits
Equity / stock options
Additional Information
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.
We are seeking a highly motivated Research Associate with a focus on Drug Metabolism and Pharmacokinetics (DMPK) to join our team. The ideal candidate will contribute to our efforts in pharmacokinetics screening, plasma protein binding, and microsomal assays.
This role offers an exciting opportunity to work in a collaborative and fast-paced environment, supporting the development of cutting-edge therapies for cardiovascular and skeletal muscle disorders.
Cytokinetics · South San Francisco, CA