Scientist

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Additional Information

Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process. Job Category: Academic Staff Employment Type: Regular Job Profile: Scientist I Job Summary: The Engin Lab in the Department of Biomolecular Chemistry is looking for a Scientist to contribute to our focus in understanding the mechanism of type 1 diabetes. The Engin Laboratory is focused on understanding how cellular stress response and organelle dysfunction plays a role in beta cell physiology and pathology. Current projects involve studying molecular mechanisms of cellular stress responses in pancreatic beta cells in autoimmune diabetes, ER-mitochondria communication, cellular senescence and the crosstalk between stressed beta cells and immune cells. The work involves working with the beta cell or immune cell-specific mouse models of the stress response genes and mechanistic studies using cell culture (primary mouse and human islets), biochemical and immunological assays (Engin et al., Sci Transl Med 2013, Lee et al, Cell Metab 2020, Chen, et al., Nat Comm 2022). More information about our research and publications can be found at enginlab.org . The Engin Lab offers training on grant writing, supports lab members to attend national meetings and disseminate their science. Candidate will be expected to: Design and conduct experimental work using state of the art technologies, both in vitro and in vivo. Perform data analysis and interpretation of results as required. Participate in multidisciplinary research collaborations. Write technical documents for fellowships and grants and craft manuscripts for publication. Present data in group meetings, seminars and conferences. Assist with training of junior scientists, students and technicians in the lab Contribute to shared lab duties Candidates who demonstrate the following knowledge, skills and abilities will be given first consideration Molecular biology, RNA, protein work and cloning At least three years of experience with mammalian cell culture. Gene manipulation including adeno or lentiviral transduction, siRNA or CRISPR-mediated knockdown. Flow cytometry (complex panel with more than 8 colors) Confocal imaging of cells and tissues. Prior knowledge of cell stress or senescence Applicants for this position will be considered for Scientist I and Scientist II titles. The title is determined by the experience and qualifications of the finalist. Key Job Responsibilities: Conducts literature reviews, prepares reports and materials, and disseminates information to appropriate entities Writes or assists in developing grant applications and proposals to secure research funding Collects and analyzes research data, conducts experiments and interviews, and documents results according to established policies and procedures under general supervision and limited responsibility Attends and assists with the facilitation of scholarly events and presentations in support of continued professional development and the dissemination of research information Assists with the identification of research problems and the development of research methodologies and procedures Serves as a main point of contact and liaison with internal and external stakeholders providing information and representing the interests of a specialized research area Department: School of Medicine and Public Health, Department of Biomolecular Chemistry, Engin Laboratory The mission of the Department of Biomolecular Chemistry (BMC) is to carry out world class research that addresses molecular mechanisms of biological processes, particularly as it relates to human disease, and to disseminate that knowledge through teaching and training of future scientists, physicians, and health science professionals. The advancement and transmission of knowledge is part of the broader mission of the School of Medicine and Public Health (SMPH) and the University. Additionally, BMC faculty members provide service and expert advice to the SMPH and other units of the University, and the state, nation, and world. In its research, teaching, service, and outreach efforts alike, BMC is committed to building a community that is open to and accepting of all. For the past century, the Department of Biomolecular Chemistry has excelled in research, teaching and service as a proud member of the School of Medicine and Public Health. Our research is at the forefront of biochemical research, integrating fundamental molecular mechanisms with human disease. Our key strengths in Biochemistry, Cell Biology, Genomics, and Development make us a nexus for collaborative studies between basic scientists and clinicians.