Senior Scientist I, Multi-specific Biologics

Responsibilities

• Responsible for design, engineering and production of multispecific biologics to support oncology
• Evaluate and integrate state-of-the-art technology to improve therapeutic production platforms, and demonstrate creative "out-of-the-box" thinking to solve difficult problems
• Serve as a Multispecifics Engineering representative for cross-functional teams, and contribute scientific insights into multiple projects across various therapeutic areas; recognized expert in multispecifics design and production
• Serve as the Biologics lead on projects to coordinate activities and transitions from hit generation through candidate nomination
• Identify and solve technical problems independently, conceive and implement innovative process research ideas
• Ensure consistency and quality of technical reports
• Provide project update, analysis and advice to cross-functional teams and senior management
• Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed scientific papers or patents
• PhD, MS, or BS degree in Biochemistry, Biochemical engineering or related disciplines with typically 0+ (PhD), 8+ (MS), or 10+ (BS) years of experience, ideally in multispecifics biologics engineering
• Extensive experience with protein, biologics, fragments, and multi-specifics design, expression and purification
• Experience with purification and automation instruments e.g. Akta, Kingfisher, Hamilton
• Sound scientific understanding of current state of protein expression/separation/analytical technologies and ability to explore and develop new approaches for innovative purification
• Experience with CRO coordination
• Experience with in vitro analytical techniques for protein characterization (e.g. SEC, MS, DSF); experience with developability screening for multispecifics preferred
• Strong molecular biology skills (e.g. molecular cloning) and experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
• Knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
• Excellent organizational skills and the ability to manage multiple projects simultaneously and adapt to rapid change in priorities
• Candidate must be a goal-oriented team player with excellent verbal and written communication skills, ability to operate in a fast-paced multi-disciplinary environment, and strong can-do attitude
• Recognized in the scientific community through a sustained record of peer-reviewed publications and patents preferred
• Key AbbVie Competencies:
• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance
• Learns fast, grasps the "essence" and can change the course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others, nurtures innovation and manages innovation to reality
• Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Benefits

Additional Information

Discovery Biotherapeutics at AbbVie is seeking a highly skilled and self-motivated scientist to join a dynamic team supporting design, engineering, and manufacturing of multispecifics. This position will impact projects through engineering, production, and characterization of multispecific biopharmaceutical products. The ideal candidate should have extensive experience with biologics and multispecifics production platforms, analytical characterization, and a proven track record implementing multispecific engineering and production strategies to advance early- and late-stage discovery programs. The applicant should be an enthusiastic, creative scientist who will make tangible contributions to the continuous improvement and innovation within the organization.

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